MICROCYSTIN-LR

Bezeichnung:MICROCYSTIN-LR

CAS-Nr101043-37-2

Englisch Name:MICROCYSTIN-LR

CBNumberCB9463679

SummenformelC49H74N10O12

Molgewicht995.17

MOL-Datei101043-37-2.mol

MICROCYSTIN-LR physikalisch-chemischer Eigenschaften

Dichte	1.29±0.1 g/cm3(Predicted)
Flammpunkt	11 °C
storage temp.	−20°C
Löslichkeit	ethanol: 1 mg/mL
pka	3.03±0.70(Predicted)
Aggregatzustand	solid film
Farbe	Off-white
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol or ethanol may be stored at -20°C for up to 2 months.
IARC	2B (Vol. 94) 2010
EPA chemische Informationen	Microcystin LR (101043-37-2)

Sicherheit

Kennzeichnung gefährlicher	T+,T,F
R-Sätze:	26/27/28-36/37/38-43-39/23/24/25-23/24/25-11
S-Sätze:	26-36/37/39-45-36/37-16-7
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS-Nr.	GT2810000
HS Code	30029090
Giftige Stoffe Daten	101043-37-2(Hazardous Substances Data)
Toxizität	LD50 orl-rat: >5 mg/kg HETOEA 18,162,1999

Gefahreninformationscode (GHS)

MICROCYSTIN-LR Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC₅₀= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM. The PP1 IC₅₀ is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.
Definition
ChEBI: Microcystin-LR is a microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins. It has a role as a bacterial metabolite, an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor, a xenobiotic and an environmental contaminant.
Hazard
A poison by ingestion and inhalation.
Sicherheitsprofil
A poison by ingestion, inhalation,intraperitoneal, and intravenous route. Experimentalreproductive effects. When heated to decomposition itemits toxic vapors of NOx.
Einzelnachweise
1) Rinehart?et al.?(1988),?Nodularin, microcystin, and the configuration of Adda; J. Am. Chem. Soc.,?110?8557 2) Honkanen?et al. (1990),?Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases;?J. Biol. Chem,?265?19401 3) Runnegar?et al.?(1995),?Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters; Toxicol. Appl. Pharmacol.,?134?264

MICROCYSTIN-LR Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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