ALPHA-APO-OXYTETRACYCLINE

Bezeichnung:ALPHA-APO-OXYTETRACYCLINE

CAS-Nr18751-99-0

Englisch Name:ALPHA-APO-OXYTETRACYCLINE

CBNumberCB9455892

SummenformelC22H22N2O8

Molgewicht442.42

MOL-Datei18751-99-0.mol

ALPHA-APO-OXYTETRACYCLINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	200-204 °C
Siedepunkt	742.4±60.0 °C(Predicted)
Dichte	1.62±0.1 g/cm3(Predicted)
storage temp.	Refrigerator, Under Inert Atmosphere
Löslichkeit	Aqueous Base (Slightly), Methanol (Slightly, Heated, Sonicated)
Aggregatzustand	Powder
pka	1.62±0.58(Predicted)
Farbe	Yellow-brown to brown
Stabilität	Unstable in basic solution
EPA chemische Informationen	1-Cyclohexene-1-carboxamide, 4-(1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl)-3-(dimethylamino)-2,5-dihydroxy-6-oxo- (18751-99-0)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	63
S-Sätze:	45-36/37
HS Code	29413020

Gefahreninformationscode (GHS)

ALPHA-APO-OXYTETRACYCLINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC₅₀ value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC₅₀ values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli. β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.
Chemische Eigenschaften
yellow-brown to brown powder
Verwenden
β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-Apooxytetracycline is an important standard for monitoring oxytetracycline stability.
Verwenden
β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. An initial dehydration to anhydrooxytetracycline then undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-apooxytetracycline is an important standard for monitoring oxytetracycline stability.
Verwenden
Oxytetracycline metabolite (absolute stereochemistry unknown)

ALPHA-APO-OXYTETRACYCLINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

18751-99-0, ALPHA-APO-OXYTETRACYCLINE Verwandte Suche:

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