trans-(4-(trifluoromethyl)cyclohexyl)methanol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

trans-(4-(trifluoromethyl)cyclohexyl)methanol Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  133261-33-3

  

  1202577-61-4

  To a suspension of lithium aluminum hydride (11.6 g, 0.306 mol) in anhydrous tetrahydrofuran (350 mL) was added slowly and dropwise anhydrous tetrahydrofuran solution (50 mL) of trans-4-(trifluoromethyl)cyclohexanecarboxylic acid (30 g, 0.153 mol) at 0 °C. The reaction mixture was stirred continuously at 0°C for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was petroleum ether:ethyl acetate = 10:1) to confirm complete consumption of raw materials. The reaction was quenched sequentially with water (12 mL), 15% aqueous sodium hydroxide solution (24 mL) and water (12 mL). The reaction mixture was filtered and the filtrate was concentrated under reduced pressure to give trans-(4-(trifluoromethyl)cyclohexyl)methanol (24 g, 86% yield) as a colorless liquid. The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 3.49-3.50 (d, J = 6.0 Hz, 2H), 1.91-2.07 (m, 4H), 1.50-1.57 (m, 1H), 1.32-1.36 (m, 2H), 0.98-1.05 (m, 2H).

• Einzelnachweise

  [1] Patent: WO2016/61160, 2016, A1. Location in patent: Paragraph 00172
  [2] Patent: US2011/53974, 2011, A1. Location in patent: Page/Page column 54
  [3] Patent: WO2014/123882, 2014, A1. Location in patent: Page/Page column 82
  [4] Patent: WO2017/24018, 2017, A1. Location in patent: Paragraph 00159; 00160

trans-(4-(trifluoromethyl)cyclohexyl)methanol Upstream-Materialien And Downstream Produkte

trans-(4-(trifluoromethyl)cyclohexyl)methanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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