Terazosin hydrochloride

Bezeichnung:Terazosin hydrochloride

CAS-Nr63074-08-8

Englisch Name:Terazosin hydrochloride

CBNumberCB9285510

SummenformelC19H26ClN5O4

Molgewicht423.9

MOL-Datei63074-08-8.mol

Terazosin hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	261-263°C
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	H₂O: 25 mg/mL
Aggregatzustand	powder
Farbe	white to off-white
Wasserlöslichkeit	Soluble in water at 20mg/ml. Also soluble in methanol or ethanol.
Stabilität	Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS Datenbank	63074-08-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	TK8044925

Gefahreninformationscode (GHS)

Terazosin hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Terazosin hydrochloride is a highly water-soluble antihypertensive agent with a structure and profile closely related to that of prazosin.
Originator
Abbott (USA)
Verwenden
An α-1-adrenergicblocker related to prazosin.
Verwenden
Hytrin (Abbott).
Verwenden
Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies⁵. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods⁶.
Trademarks
Terazosin is INN and BAN;HEITRIN.
Allgemeine Beschreibung
Terazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride (Hytrin), is a structuralcongener of prazosin hydrochloride. It possessessimilar selective properties of specifically inhibiting 1-adrenergic receptors. The drug is slightly less potent thanprazosin hydrochloride. Terazosin hydrochloride has a halflifeof approximately 12 hours, which is much longer thanthat of prazosin. This lends itself to a once-daily dose tocontrol hypertension in many patients.
Biologische Aktivität
α 1 - and α 2B -adrenoceptor antagonist (K i values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α 1A , α 1B , α 1D , α 2B , α 2A and α 2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo .
Biochem/physiol Actions
α1-adrenoceptor antagonist.
Lager
Store at RT
Einzelnachweise
References/Citations 1) Hancock et al. (1995), Actions of terazosin and its enantiomers at subtypes of alpha-1 and alpha-2 adrenoceptors in vitro; Recept. Signal Transduct. Res., 15 863 2) Kyncl et al. (1986), Pharmacology of terazosin; Am. J. Med., 80 12 3) Shionoiri et al. (1994), Long-term therapy with terazosin may improve glucose and lipid metabolism in hypertensives: a multicenter prospective study; Am. J. Med. Sci., 307 Suppl 1 S91 4) Pan et al. (2003), Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells; J. Urol., 169 724 5) Chen et al. (2015), Terazosin activates Pgk1 and HSP90 to promote stress resistance; Nat. Chem. Biol., 11 19

Terazosin hydrochloride Upstream-Materialien And Downstream Produkte

Terazosin hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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