Bunazosin hydrochloride

Bunazosin hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Bunazosin hydrochloride is a selective αl-adrenergic antagonist related to prazosin and useful in the treatment of hypertension.

• Originator

  Eisai (Japan)

• Verwenden

  Bunazosin Hydrochloride is an α-1 adrenergic receptor antagonist that acts as an anti-cancer and anti-glaucoma drug.

• Definition

  ChEBI: Bunazosin hydrochloride is a member of quinazolines.

• Manufacturing Process

  17.0 g of 2-chloro-4-amino-6,7-dimethoxyquinazoline and 18.2 g of Nformylhomopiperazine are added to 170 ml of butanol and the whole is refluxed with stirring for 3 h. After completion of the reaction, the mixture is cooled, and the crystals thus precipitated are filtered out, washed with a small quantity of ethanol and air-dried. 25.0 g of crude 2-homopiperazino-4-amino- 6,7-dimethoxyquinazoline are obtained.
  A solution of 2-homopiperazino-4-amino-6,7-dimethoxyquinazoline in 60 ml of acetone is added dropwise to a solution of 2-butylcarboxylic acid chloride in acetone under stirring and ice-cooling. After completion of the addition, the stirring is continued for additional 1 h to complete the reaction. The crystals thus precipitated are filtered out and the 1-(4-amino-6,7-dimethoxy-2- quinazolinyl)hexahydro-4-(1-oxobutyl)-1H-1,4-diazepine, melting point 280- 282°C (recrystallized from a mixture of methanol-ethanol) is obtained.

• Trademarks

  DETANTOL

• Therapeutic Function

  Antihypertensive

Bunazosin hydrochloride Upstream-Materialien And Downstream Produkte

Bunazosin hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(42)Suppliers

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