N-Methyl-D-aspartic acid

Bezeichnung:N-Methyl-D-aspartic acid

Englisch Name:N-Methyl-D-aspartic acid

CBNumberCB8854056

SummenformelC5H9NO4

Molgewicht147.13

N-Methyl-D-aspartic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	187-192 °C
alpha	-28 º (c=1, HCl 6N)
Siedepunkt	267.21°C (rough estimate)
Dichte	1.4285 (rough estimate)
Brechungsindex	-15 ° (C=2, H2O)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly)
Aggregatzustand	solid
pka	2.21±0.23(Predicted)
Farbe	white
Wasserlöslichkeit	slightly soluble
Sensitive	Hygroscopic
Merck	14,6662
BRN	1724431
LogP	1.390 (est)
CAS Datenbank	6384-92-5(CAS DataBase Reference)

Sicherheit

Gefahreninformationscode (GHS)

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to off-white crystalline powder
Verwenden
NMDA agonist
Verwenden
NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
Definition
ChEBI: An aspartic acid derivative having an N-methyl substituent and D-configuration.
Allgemeine Beschreibung
N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.
Biologische Aktivität
Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset™ .
Biochem/physiol Actions
Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.
Lager
Room temperature
Einzelnachweise
[1] watkins jc, jane de. the glutamate story. br j pharmacol. 2006 jan;147 suppl 1:s100-8.
[2] lafon-cazal m, pietri s, culcasi m, bockaert j. nmda-dependent superoxide production and neurotoxicity. nature. 1993 aug 5;364(6437):535-7.