Potassium canrenoate Struktur

Kaliumcanrenoat

Bezeichnung:Kaliumcanrenoat

CAS-Nr2181-04-6

Englisch Name:Potassium canrenoate

CBNumberCB8774235

SummenformelC11H15KO2

Molgewicht218.33

MOL-Datei2181-04-6.mol

Synonyma

Kaliumcanrenoat

Kaliumcanrenoat physikalisch-chemischer Eigenschaften

Schmelzpunkt	242-244°C (dec.)
Dichte	1.345 g/cm3
storage temp.	Refrigerator
Löslichkeit	Methanol (Slightly)
Aggregatzustand	powder
Farbe	light yellow to tan
CAS Datenbank	2181-04-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
WGK Germany	3
RTECS-Nr.	TU3500000
Toxizität	LD50 oral in rat: 650mg/kg

Gefahreninformationscode (GHS)

Potassium canrenoate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Originator
Spiroctan,Boehringer Mannheim,Switz.,1968
Verwenden
anticholithogenic, antilipemic agent
Verwenden
Canrenoic acid is an aldosterone antagonist. Canrenoic acid is used as an diuretic.
Manufacturing Process
The lactone is prepared as follows: A solution of 5 parts of 17α-carboxyethyl- 17β-hydroxyandrost-4-en-3-one lactone and 5 parts of chloranil in 400 parts of xylene containing a trace of p-toluenesulfonic acid is heated at the boiling point of the solvent under reflux overnight. The solution is then cooled and filtered through approximately 200 parts of silica gel. The gel is successively washed with 5%, 10%, and 15% ethyl acetate-benzene solutions, and the washings comprising 15% ethyl acetate are thereupon purified by chromatography on a further quantity of silica gel, using benzene and ethyl acetate as developing solvents. From the 15% ethyl acetate eluate there is obtained pure 17α-carboxyethyl-17β-hydroxyandrost-4,6-dien-3-one lactone, melting at 148° to 151°C. The product solidifies above this melting point and melts again at 165°C.
Trademarks
Aldactone-diurapid;Aldadiene potassium;Kadiur;Lasiren;Luvion;Osirenol;Osyrol-lasix;Phanurane;Sincomen pro injectione;Speroctan-m;Spiroctan.
Therapeutic Function
Aldosterone antagonist, Diuretic
Weltgesundheitsorganisation (WHO)
Potassium canrenoate, which has no intrinsic aldosterone antagonist activity, owes its therapeutic effect to the enzymatic interconversion in the body to canrenone. Evidence that long-term administration of high doses are tumorigenic in the rat has recently led to restriction of its use by some national regulatory authorities. See also WHO comments for canrenone and spironolactone.

Potassium canrenoate Upstream-Materialien And Downstream Produkte

Kaliumcanrenoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2181-04-6, Potassium canrenoate Verwandte Suche:

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