L-(+)-Homoargininhydrochlorid

Bezeichnung:L-(+)-Homoargininhydrochlorid

CAS-Nr1483-01-8

Englisch Name:L(+)-Homoarginine hydrochloride

CBNumberCB8732118

SummenformelC7H17ClN4O2

Molgewicht224.69

MOL-Datei1483-01-8.mol

Synonyma

L-(+)-Homoargininhydrochlorid

L-(+)-Homoargininhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	213-215 °C(lit.)
alpha	18 º (c=1, 1N HCl)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	H₂O: 50 mg/mL, clear to slightly hazy, faintly yellow
Aggregatzustand	Granular Powder
Farbe	White
Wasserlöslichkeit	Soluble in water(50 mg/mL).
BRN	4016621
Stabilität	Moisture Sensitive
CAS Datenbank	1483-01-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	24/25-36/37/39-27-26
WGK Germany	3
HS Code	29252900

Gefahreninformationscode (GHS)

L(+)-Homoarginine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases. This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [³H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells. Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.
Chemische Eigenschaften
White Powder
Verwenden
An inhibitor of alkaline phosphatase isoenzymes. It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.
Verwenden
An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000).
Biochem/physiol Actions
Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.

L-(+)-Homoargininhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1483-01-8, L(+)-Homoarginine hydrochloride Verwandte Suche:

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