2-Brom-5-nitroanisol

Bezeichnung:2-Brom-5-nitroanisol

CAS-Nr77337-82-7

Englisch Name:2-Bromo-5-nitroanisole

CBNumberCB8719656

SummenformelC7H6BrNO3

Molgewicht232.03

MOL-Datei77337-82-7.mol

Synonyma

2-Brom-5-nitroanisol

2-Brom-5-nitroanisol physikalisch-chemischer Eigenschaften

Schmelzpunkt	99-103 °C
Siedepunkt	302.1±22.0 °C(Predicted)
Dichte	1.640±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Wasserlöslichkeit	Insoluble in water
Aggregatzustand	Crystalline Powder
Farbe	Light brown
maximale Wellenlänge (λmax)	324nm(EtOH)(lit.)
BRN	2520496
CAS Datenbank	77337-82-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-22
S-Sätze:	24/25-26
Hazard Note	Irritant
HS Code	29093090

Gefahreninformationscode (GHS)

2-Bromo-5-nitroanisole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
light brown crystalline powder
Synthese

97-52-9

77337-82-7

General procedure for the synthesis of 2-bromo-5-nitroanisole from 2-methoxy-4-nitroaniline: a catalytic amount of copper bromide (1 mol%) was added to a solution of 2-methoxy-4-nitroaniline (2.5 mmol) in acetonitrile (30 ml), followed by camphorsulfonic acid (3.0 mmol), sodium nitrite or tert-butyl nitrite (3.0 mmol), and tetrabutylammonium bromide (5.0 mmol). The reaction mixture was stirred at 60°C for 24 h (Tables 1 and 2). Nitrogen release was observed immediately during the reaction. After completion of the reaction (confirmed by β-naphthol test and thin layer chromatography), the solvent was removed using a rotary evaporator. The residue was washed with water and extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. Finally, purification by column chromatography using a hexane/dichloromethane solvent mixture as eluent gave the pure product 2-bromo-5-nitroanisole. The physical properties and 1H NMR data of the product were consistent with the commercially available analytically pure sample.
Einzelnachweise
[1] Tetrahedron, 2013, vol. 69, # 16, p. 3511 - 3517
[2] Tetrahedron, 2010, vol. 66, # 37, p. 7418 - 7422
[3] Tetrahedron Letters, 2010, vol. 51, # 51, p. 6769 - 6771
[4] Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 10, p. 979 - 988
[5] Journal of the American Chemical Society, 1935, vol. 57, p. 1592,1594

2-Bromo-5-nitroanisole Upstream-Materialien And Downstream Produkte

2-Brom-5-nitroanisol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

77337-82-7, 2-Bromo-5-nitroanisole Verwandte Suche:

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