4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

Bezeichnung:4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

CAS-Nr749886-87-1

Englisch Name:4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

CBNumberCB8649474

SummenformelC16H20N2

Molgewicht240.34

MOL-DateiMol file

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	104.4-105.0℃
Siedepunkt	418.7±40.0 °C(Predicted)
Dichte	1.086±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO: >10mg/mL
pka	5.99±0.11(Predicted)
Aggregatzustand	solid
Farbe	off-white to gray-pink

Sicherheit

Kennzeichnung gefährlicher	Xn,N
R-Sätze:	22-41-50/53
S-Sätze:	26-39-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
HS Code	2921.59.8090

Gefahreninformationscode (GHS)

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
A cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II, JSH-23
Verwenden
JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.
Verwenden
JSH-23 is a cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II.
Definition
ChEBI: JSH-23 is a diamine that is 1,2-phenylenediamine carrying a methyl substituent at position 4 and a 3-phenylpropyl substituent at position N1. It has a role as a NF-kappaB inhibitor. It is a diamine and a substituted aniline. It is functionally related to a 1,2-phenylenediamine.
Allgemeine Beschreibung
A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC₅₀ = 7.1 μM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
Biologische Aktivität
jsh-23 is an inhibitor of nf-κb transcriptional activity with ic50 value of 7.1μm [1].jsh-23 is developed to inhibit nf-κb transcriptional activity in lps-stimulated macrophages raw 264.7. it shows a dose-dependent inhibition. this effect is not due to its cytotoxicity. in the same condition, jsh-23 is found to significantly decrease the lps-induced dna binding activity of nf-κb while decrease nuclear amount of nf-κb p65. jsh-23 plays these roles without affecting iκb degradation. in addition, jsh-23 also shows inhibition effects on the expression of the pro-inflammatory transcripts and enzymes, including il-6, il-1β, cox-2 and tnf-α. furthermore, jsh-23 inhibits lps-induced apoptotic chromatin condensation [1].
Biochem/physiol Actions
Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity
target
NF-κB
Einzelnachweise
[1] shin hm, kim mh, kim bh, jung sh, kim ys, park hj, hong jt, min kr, kim y. inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of nf-kappab without affecting ikappab degradation. febs lett. 2004 jul 30;571(1-3):50-4.

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

749886-87-1, 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Verwandte Suche:

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