N-ACETYLPROCAINAMIDE

Bezeichnung:N-ACETYLPROCAINAMIDE

CAS-Nr32795-44-1

Englisch Name:N-ACETYLPROCAINAMIDE

CBNumberCB8432449

SummenformelC15H23N3O2

Molgewicht277.36

MOL-Datei32795-44-1.mol

N-ACETYLPROCAINAMIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	138-140 °C(lit.)
Siedepunkt	500.0±35.0 °C(Predicted)
Dichte	1.097±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	soluble1%, clear, colorless to faintly yellow (1N HCl)
Aggregatzustand	Solid
pka	14.54±0.46(Predicted)
Farbe	White to off-white
Merck	13,20

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
RIDADR	3249
WGK Germany	3
RTECS-Nr.	AE1974350
HazardClass	6.1(b)
PackingGroup	III

Gefahreninformationscode (GHS)

N-ACETYLPROCAINAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Originator
Acecainide ,ZYF Pharm Chemical
Verwenden
antiprotozoal
Verwenden
N-acetylprocainamide (NAPA) was used as a model drug in the study of establishing a quantitative approach to predict the renal clearances of basic drugs using N-1-methylnicotinamide (NMN).
Definition
ChEBI: A benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine.
Manufacturing Process
1.0 g of p-amino-N-(2-diethylaminoethyl)benzamide is dissolved in chloroform. A few ice cubes are added to the solution. Acetyl chloride is added dropwise with stirring until no more white precipitate forms; the latter is separated by filtering under suction. The precipitate is washed with cold acetone and dried overnight in a vacuum oven at room temperature. The product is dissolved in a minimum amount of hot isopropanol and allowed to precipitate in the cold. The p-acetamido-N-(2-diethylaminoethyl)benzamide hydrochloride, is recrystallized a second time from hot isopropanol, melting point 190°-193°C. The free base is obtained from the hydrochloride by dissolving the latter in water, adjusting the pH to greater than 10 with dilute sodium hydroxide, and adding an equal volume of benzene. After shaking in a separatory funnel, the benzene layer is recovered and evaporated to dryness. So the p-acetamido-N- (2-diethylaminoethyl)benzamide is obtained.
Therapeutic Function
Antiarrhythmic
Allgemeine Beschreibung
The relaxant effects of N-acetylprocainamide on bovine tracheal smooth muscle was studied.

N-ACETYLPROCAINAMIDE Upstream-Materialien And Downstream Produkte

N-ACETYLPROCAINAMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

32795-44-1, N-ACETYLPROCAINAMIDE Verwandte Suche:

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