Tioconazol

Bezeichnung:Tioconazol

CAS-Nr65899-73-2

Englisch Name:Vagistat

CBNumberCB8416704

SummenformelC16H13Cl3N2OS

Molgewicht387.71

MOL-Datei65899-73-2.mol

Synonyma

Tioconazol

Tioconazol physikalisch-chemischer Eigenschaften

Schmelzpunkt	79-81oC
Siedepunkt	534.5±50.0 °C(Predicted)
Dichte	1.3115 (rough estimate)
Brechungsindex	1.6000 (estimate)
RTECS-Nr.	NI4480000
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	Very slightly soluble in water, very soluble in methylene chloride, freely soluble in alcohol.
pka	6.66±0.12(Predicted)
Aggregatzustand	powder
Farbe	white to off-white
CAS Datenbank	65899-73-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	3
HS Code	2934990002

Gefahreninformationscode (GHS)

Vagistat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Tioconazole is an antifungal agent, closely related to miconazole. Tioconazole is effective in the topical treatment of superficial fungal infections and appears to be more potent than miconazole against Candida and Trichophyton species.
Chemische Eigenschaften
White powder EINECS: 265-973-8
Originator
Pfizer (United Kiugdom)
Verwenden
Potent inhibitor of cytochrome-P450
Verwenden
antithrombotic
Verwenden
Tioconazole is an antifungal that is more active than Fluconazole (F421000) or Voriconazole (V760000) against Candida glabrata mutant strains. Antifungal (topical).
Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, tioconazole is indicated for therapy of vulvovaginal mycoses caused by Candida species and Candida (Torulopsis) glabrata.
Definition
ChEBI: A member of the class of imidazoles that comprises 2-(2,4-dichlorophenyl)ethylimidazole carrying an additional (2-chloro-3-thienyl)methoxy substituent at position 2.
Manufacturing Process
A solution of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (1.5 g, 5.8 mmol) dissolved in dry tetrahydrofuran (10 ml) was added to a stirred suspension of sodium hydride (0.39 g, as 80% dispersion in oil, 16 mmol) in dry tetrahydrofuran (10 ml) and warmed to 70°C for 90 minutes. The mixture was cooled in ice and a solution of 2-chloro-3- chloromethylthiophene (8.8 mmol) in dry tetrahydrofuran was added. The mixture was heated at 70°C for 3 hours and allowed to stir at room temperature overnight. The solvent was removed under vacuum and the residue stirred with dry ether (200 ml). The ether solution was filtered through Celite and saturated with hydrogen chloride gas to precipitate an oil which was solidified by trituration with ether and ethyl acetate. The solid product was collected and recrystallized from a mixture of acetone and diisopropyl ether to give the product, melting point 168°C to 170°C.
Trademarks
TROSYL
Therapeutic Function
Antifungal
Antimicrobial activity
Tioconazole is a broad-spectrum imidazole antimycotic with activity against almost all species of pathogenic fungi.
Pharmakokinetik
Tioconazole is normally not absorbed after topical application to the skin [173]. On vaginal application of an ovulum containing 300 mg tioconazole, a serum concentration of 21 μg/mL was observed after 8 h.
Clinical Use
1-[2-[(2-chloro-3-thienyl)methoxy]2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole (Vagistat) is used for the treatment ofvulvovaginal candidiasis. A vaginal ointment containing6.5% of the free base is available. Tioconazole is more effectiveagainst Torulopsis glabrata than are other azoles.
Nebenwirkungen
Local irritations such as itching, burning sensations, erythema, and dermatitis, and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.

Vagistat Upstream-Materialien And Downstream Produkte

Tioconazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

65899-73-2, Vagistat Verwandte Suche:

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