Leuprorelin

Bezeichnung:Leuprorelin

CAS-Nr53714-56-0

Englisch Name:Leuprorelin

CBNumberCB8398455

SummenformelC59H84N16O12

Molgewicht1209.4

MOL-Datei53714-56-0.mol

Leuprorelin physikalisch-chemischer Eigenschaften

alpha	D25 -31.7° (c = 1 in 1% acetic acid)
Dichte	1.44±0.1 g/cm3(Predicted)
storage temp.	−20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka	9.82±0.15(Predicted)
Wasserlöslichkeit	Soluble in water at 1mg/ml
Stabilität	Hygroscopic
InChIKey	RGLRXNKKBLIBQS-VAZQWRJQNA-N
CAS Datenbank	53714-56-0(CAS DataBase Reference)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	2
RTECS-Nr.	OH6390000
Giftige Stoffe Daten	53714-56-0(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Leuprorelin Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Hygroscopic, white or almost white powder.
Originator
Eligard,Atrix Laboratories, Inc.
Verwenden
Highly active luteinizing hormone releasing hormone (LHRH) agonist
Verwenden
Gonadotropin releasing hormone (gonadorelin) analogue; treatment of prostate cancer.
Definition
ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. Leuprorelin is a synthetic nonapeptide analogue of gonadotropin-releasi g hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
Indications
Leuprolide is a potent LH-RH agonist for the first several days to a few weeks after initiation of therapy, and therefore, it initially stimulates testicular and ovarian steroidogenesis. Because of this initial stimulation of testosterone production, it is recommended that patients with prostatic cancer be treated concurrently with leuprolide and the antiandrogen flutamide (discussed earlier). Leuprolide is generally well tolerated, with hot flashes being the most common side effect.
Therapeutic Function
Antineoplastic
Synthese
The synthesis process of Leuprorelin includes the following steps:
(1) Fmoc-Pro-HMPB-AM resin is obtained from Fmoc-Pro-OH and HMPB-AM resin with a substitution degree of 0.2mmol/g～1.2mmol/g as starting materials;
(2) The Fmoc-Pro-HMPB-AM resin was coupled one by one by Fmoc/tBu solid phase method to connect amino acids with protective groups in sequence, and the side chain fully protected leuprolide precursor peptide-HMPB-AM was synthesized Resin;
(3) Cut the side chain fully protected leuprolide precursor peptide-HMPB-AM resin to obtain the side chain fully protected leuprolide precursor peptide;
(4) Fully protected side chain leuprolide precursor peptide undergoes ethylamination to obtain side chain fully protected leuprolide;
(5) Leuprolide is fully protected on the side chain by removing the side chain protecting group to obtain the crude leuprolide peptide;
(6) The crude leuprorelin peptide is separated and purified by a high-pressure liquid phase column and lyophilized to obtain the leuprolide refined peptide.

Leuprorelin Upstream-Materialien And Downstream Produkte

Leuprorelin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

53714-56-0, Leuprorelin Verwandte Suche:

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