Atropinsulfat

Bezeichnung:Atropinsulfat

CAS-Nr55-48-1

Englisch Name:Atropine sulfate

CBNumberCB8315445

Summenformel2C17H23NO3.H2O4S

Molgewicht676.82

MOL-Datei55-48-1.mol

Synonyma

Atropinsulfat

Atropinsulfat physikalisch-chemischer Eigenschaften

Schmelzpunkt	189-192 °C (A)(lit.)
Siedepunkt	135 °C
Dichte	1.1172 (rough estimate)
Brechungsindex	1.6900 (estimate)
storage temp.	0-6°C
Löslichkeit	Soluble in DMSO
Farbe	Crystals
InChIKey	HOBWAPHTEJGALG-AADVZIIPNA-N
CAS Datenbank	55-48-1(CAS DataBase Reference)
EPA chemische Informationen	Atropine sulfate (55-48-1)

Sicherheit

Kennzeichnung gefährlicher	T+
R-Sätze:	26/28
S-Sätze:	23-45
RIDADR	UN 1544 6.1/PG 2
WGK Germany	2
F	3-8-10
Toxizität	LD50 oral in rat: 600mg/kg

Gefahreninformationscode (GHS)

Atropine sulfate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R26/28:Sehr giftig beim Einatmen und Verschlucken.
S-Sätze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Verwenden
anticholinergic agent
Verwenden
cholinergic receptor antagonist
Trademarks
Atrophate [Veterinary] (Schering-Plough Animal Health); Atropisol (Ciba Vision, US Ophthalmics); Isopto Atropine (Alcon).
Allgemeine Beschreibung
Atropine sulfate (Atropisol)is prepared by neutralizing atropine in acetone or ethersolution with an alcoholic solution of sulfuric acid, withcare used to prevent hydrolysis. The salt occurs as colorlesscrystals or as a white, crystalline powder. It is efflorescentin dry air and should be protected from light to preventdecomposition.
Atropine sulfate is freely soluble in water (1:0.5), in alcohol(1:5, 1:2.5 at boiling point), and in glycerin (1:2.5).Aqueous solutions are not very stable, although solutionsmay be sterilized at 120°C (15 lb pressure) in an autoclave if the pH is kept below 6. Sterilization probably is besteffected by the use of aseptic techniques and a bacteriologicalfilter. It has been suggested that no more than a 30-daysupply of an aqueous solution should be made and that forsmall quantities the best procedure is to use hypodermictablets and sterile distilled water. Kondritzer andZvirblis have studied the kinetics of alkaline and protoncatalyzedhydrolyses of atropine in aqueous solution. Theregion of maximal stability lies between pH 3 and approximately5. They have also proposed an equation to predictthe half-life of atropine undergoing hydrolysis at constantpH and temperature.
Clinical Use
Atropine may be used to treat some types of arrhythmias. Itincreases the heart rate by blocking the effects of ACh on thevagus. In this context, it is used to treat certain reversible bradyarrhythmiasthat may accompany acute myocardial infarction.It is also used as an adjunct to anesthesia to protect againstbradycardia, hypotension, and even cardiac arrest induced bythe skeletal muscle relaxant succinylcholine chloride.
Another use for atropine sulfate emerged following thedevelopment of the organophosphates, which are potent inhibitorsof AChE. Atropine is a specific antidote to preventthe muscarinic effects of ACh accumulation, such as vomiting,abdominal cramps, diarrhea, salivation, sweating, bronchoconstriction,and excessive bronchial secretions. It isused intravenously but does not protect against respiratoryfailure caused by depression of the respiratory center andthe muscles of respiration.
Sicherheitsprofil
Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human (child) pulmonary system effects by ingestion. Human systemic effects: decreased body temperature, cardiac arrhythmias. An experimental teratogen. Other experimental reproductive effects. See also ATROPINE. When heated to decomposition it emits very toxic fumes of NO,xand SOx.
Veterinary Drugs and Treatments
The principal veterinary indications for systemic atropine include:
!!Preanesthetic to prevent or reduce secretions of the respiratory tract
!!Treat sinus bradycardia, sinoatrial arrest, and incomplete AV block
!!Differentiate vagally-mediated bradycardia for other causes
!!As an antidote for overdoses of cholinergic agents (e.g., physostigmine, etc.)
!!As an antidote for organophosphate, carbamate, muscarinic mushroom, blue-green algae intoxication
!!Hypersialism
!!Treatment of bronchoconstrictive disease

Atropinsulfat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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