3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

Bezeichnung:3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

CAS-Nr67416-61-9

Englisch Name:3-ACETYL-11-KETO-BETA-BOSWELLIC ACID

CBNumberCB8309086

SummenformelC32H48O5

Molgewicht512.73

MOL-Datei67416-61-9.mol

3-ACETYL-11-KETO-BETA-BOSWELLIC ACID physikalisch-chemischer Eigenschaften

Schmelzpunkt	271℃
Siedepunkt	600.3±55.0 °C(Predicted)
Dichte	1.13±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
Löslichkeit	Chloroform (Sparingly), Methanol (Slightly)
pka	4.28±0.70(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
LogP	7.418 (est)

Sicherheit

R-Sätze:	36/37/38
S-Sätze:	26
WGK Germany	3
HS Code	2918300000

Gefahreninformationscode (GHS)

3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC₅₀ = 1.5 μM) in an enzyme-directed, nonredox, and noncompetitive manner. 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.
Verwenden
3-Acetyl-11-keto-β-boswellic Acid (AKBA), be used in the place of the non-steroidal anti-inflammatory drug. AKBA, also inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway. It can be used as an anticancer agent.
Definition
ChEBI: 3-Acetyl-11-keto-beta-boswellic acid is a triterpenoid.
in vitro
akba exerted a time- and concentration -dependent cytotoxicity on androgen-independent prostate cancer cells. akba blocked proliferation and elicited apoptosis in the chemoresistant and androgen-independent human pc-3 prostate cancer cells by the release of mitochondrial cytochrome c and dna fragmentation. also, akba concentration-dependently inhibited nf-κb signaling, yet it did not directly affect the nf-κb binding to dna. additionally, akba suppressed inhibitor κb kinase and nf-κb-dependent antiapoptotic gene products in pc-3 cells [1].
in vivo
pc-3 xenotransplanted male nmri/nu-nu mice were injected intraperitoneally at 100 μmol/kg daily for three weeks. akba dampened growth and proliferation of pc-3 xenografts in nude mice and elicited apoptosis. moreover, compared with the control group, akba reduced the tumor volume and the invasiveness of the tumor into the surrounding tissues [1].
IC 50
1.5 μm
Einzelnachweise
[1]. syrovets, t., gschwend, j., buchele, b., laumonnier, y., zugmaier, w., genze, f., & simmet, t. inhibition of iκb kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent pc-3 prostate cancer cells in vitro and in vivo. journal of biological chemistry. 2004; 280(7): 6170-6180.

3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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