3-(Trifluormethyl)zimtsaeure

Bezeichnung:3-(Trifluormethyl)zimtsaeure

CAS-Nr779-89-5

Englisch Name:3-(Trifluoromethyl)cinnamic acid

CBNumberCB8295905

SummenformelC10H7F3O2

Molgewicht216.16

MOL-Datei779-89-5.mol

Synonyma

3-(Trifluormethyl)zimtsaeure

3-(Trifluormethyl)zimtsaeure physikalisch-chemischer Eigenschaften

Schmelzpunkt	135-137 °C(lit.)
Siedepunkt	224°C (rough estimate)
Dichte	1.3275 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	4.25±0.10(Predicted)
Farbe	White to Off-White
BRN	1963372
CAS Datenbank	779-89-5(CAS DataBase Reference)
EPA chemische Informationen	3-[3-(Trifluoromethyl)phenyl]acrylic acid (779-89-5)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38-37/38
S-Sätze:	26-37/39-37
WGK Germany	3
TSCA	Yes
HazardClass	IRRITANT
HS Code	29163990

Gefahreninformationscode (GHS)

3-(Trifluoromethyl)cinnamic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R37/38:Reizt die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S37:Geeignete Schutzhandschuhe tragen.
Chemische Eigenschaften
White Solid
Verwenden
Had sedative hypnotic activity in mice, showing potent inhibition of spontaneous motility.
Verwenden
3-(Trifluoromethyl)cinnamic acid is used in the synthesis of cinacalcet. Cinacalcet is a drug for the control and treatment of secondary hyperparathyroidism (in the dialysis population), primary hyperparathyroidism where the patient may not be a candidate for surgical treatment, and for the treatment of calciphylaxis in patients with end-stage renal disease or in patients on dialysis.
Definition
ChEBI: (E)-3-(trifluoromethyl)cinnamic acid is a member of the class of (trifluoromethyl)benzenes consisting of trans-cinnamic acid having a trifluoromethyl substituent at the meta-position. It is a member of cinnamic acids, a member of styrenes and a member of (trifluoromethyl)benzenes. It is functionally related to a trans-cinnamic acid.
Synthese
To a suspension of m-trifluoromethyl-α-bromohydrocinnamic acid, isopropanol (1.42 1) and benzyltriethylammonium chloride (10.85g), aqueous sodium hydroxide (340 ml, 56%) was added slowly. The temperature was raised to 55-60℃, stirred for 7 hours, and isopropanol was removed in vacuo. Water (500ml) was added to the reaction mass, stirred, cooled to 0℃, and acidified with hydrochloric acid (450ml). The solid was filtered, washed with water, and dried in vacuo at 5O℃ to afford 204g of 3-(Trifluoromethyl)cinnamic acid.

3-(Trifluoromethyl)cinnamic acid Upstream-Materialien And Downstream Produkte

3-(Trifluormethyl)zimtsaeure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

779-89-5, 3-(Trifluoromethyl)cinnamic acid Verwandte Suche:

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