6-HYDROXY-2-NAPHTHYL DISULFIDE Struktur

6,6'-Dithiodi-2-naphthol

Bezeichnung:6,6'-Dithiodi-2-naphthol

CAS-Nr6088-51-3

Englisch Name:6-HYDROXY-2-NAPHTHYL DISULFIDE

CBNumberCB8198578

SummenformelC20H14O2S2

Molgewicht350.45

MOL-Datei6088-51-3.mol

Synonyma

6,6'-Dithiodi-2-naphthol

6,6'-Dithiodi-2-naphthol physikalisch-chemischer Eigenschaften

Schmelzpunkt	226 °C
Siedepunkt	597.5±25.0 °C(Predicted)
Dichte	1.46±0.1 g/cm3(Predicted)
storage temp.	−20°C
Löslichkeit	<26.28mg/ml in DMSO
Aggregatzustand	powder to crystal
pka	8.93±0.40(Predicted)
Farbe	White to Brown
Merck	14,2840
CAS Datenbank	6088-51-3(CAS DataBase Reference)
EPA chemische Informationen	2-Naphthalenol, 6,6'-dithiobis- (6088-51-3)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
HS Code	2908990090

Gefahreninformationscode (GHS)

6-HYDROXY-2-NAPHTHYL DISULFIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
DDD, 1,1-dichloro-2,2-bis-(4-chlorophenyl) ethane, also known as TDE, is a metabolite of DDT, which found use in agriculture. As with DDT, the p,p -isomer is insecticidal and the o,p -isomer is an impurity.
Verwenden
For determination of protein-bound sulfhydryl groups.
läuterung methode
It crystallises as leaflets from AcOH and is slightly soluble in EtOH, and AcOH, but is soluble in *C6H6 and in alkalis to give a yellow solution. [Zincke & Dereser Chem Ber 51 352 1918.] The acetoxy derivative has m 198-200o (from AcOH or dioxane/MeOH), and the diacetyl derivative has m 167-168o (from AcOH). A small amount of impure disulfide can be purified by dissolving it in a small volume of Me2CO and adding a large volume of toluene, filter rapidly and concentrate to one-third of its volume. The hot toluene solution is filtered rapidly from any tarry residue, and crystals separate on cooling. Recrystallisation from hot acetic acid gives crystals with m 220-223o [Barrett & Seligman Science 116 323 1952]. [Beilstein 6 I 481.]
Toxicity evaluation
Animal Studies. DDD is less acutely toxic than DDT (29), with an oral LD₅₀ of 3400 to 4000 mg/kg in the rat and a dermal LD₅₀ ca. 1200 mg/kg in the rabbit. In a 2-year chronic dietary study in the rat, a LOEL of 100 ppm (5 mg/kg/day) was quoted for tissue damage, similar to that produced by DDT.
Human Studies. Most of the studies conducted in humans have used the o,p -isomer of DDD. This has been used as a drug, with medical and veterinary uses, for the treatment of Cushing’s syndrome and adrenal carcinoma, under the generic name of mitotane. After oral ingestion, o,p’-DDD binds to lung and adrenal tissue. Its toxicity to the adrenal appears to be species-dependent, however, causing gross atrophy in the dog and reducing corticosteroid production without pathological effects in other mammals, including humans.

6-HYDROXY-2-NAPHTHYL DISULFIDE Upstream-Materialien And Downstream Produkte

6,6'-Dithiodi-2-naphthol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6088-51-3, 6-HYDROXY-2-NAPHTHYL DISULFIDE Verwandte Suche:

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