Danusertib

Bezeichnung:Danusertib

CAS-Nr827318-97-8

Englisch Name:Danusertib

CBNumberCB81518500

SummenformelC26H30N6O3

Molgewicht474.55

MOL-Datei827318-97-8.mol

Danusertib physikalisch-chemischer Eigenschaften

Schmelzpunkt	>145°C (dec.)
Siedepunkt	664.1±55.0 °C(Predicted)
Dichte	1.322
storage temp.	Refrigerator
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	13.70±0.20(Predicted)
Farbe	Pale Beige

Gefahreninformationscode (GHS)

Danusertib Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
An Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia. It is a COVID19-related research product.
Verwenden
Danusertib is an Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia.
Definition
ChEBI: N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide is a member of piperazines.
Biologische Aktivität
danusertib (previously known as pha-739358), a 3-aminopyrazole derivative identified during the development of the pyrrolopyrazole sub-series, is a potent small-molecule inhibitor of aurora kinases family members with a dominant inhibition for aurora b kinase (abk). this pan-aurora kinases inhibitor is also able to inhibit several tyrosine kinases, including t315i mutant, ret, trk-a and fibroblast growth factor receptor-1 (fgfr-1), which are involved in multiple malignancies, such as chronic myelogenous leukemia (cml), acute lymphoblastic leukemia (all), thyroid prostate and breast carcinoma. thus, in many previous studies, danusertib exhibits remarkable antitumor activity in a number of different xengorafts, spontaneous, and transgenic animal tumor models with a favorable pharmacokinetic and safety profile.carpinelli p, ceruti r, giorgini ml, cappella p, gianellini l, croci v, degrassi a, texido g, rocchetti m, vianello p, rusconi l, storici p, zugnoni p, arrigoni c, soncini c, alli c, patton v, marsiglio a, ballinari d, pesenti e, fancelli d, moll j. pha-739358, a potent inhibitor of aurora kinases with a selecyive target inhibiton profile relevant to cancer. mol cancer ther 2007; 6(12 pt 1): 3158-3168
target
Aurora A/B/C

Danusertib Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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