Ditazol

ditazole Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Ageroplas,Serona,Italy,1973

• Verwenden

  Ditazole is a weak anti-inflammatory drug and a novel inhibitor of platelet aggregation.

• Definition

  ChEBI: Ditazole is a member of 1,3-oxazoles.

• Manufacturing Process

  A solution of 5.1 grams 2-chloro-4,5-diphenyl-oxazole, 6.3 grams diethanolamine and 50 ml absolute ethanol was refluxed for 4 hours. The solvent was stripped at 1 mm and the oily residue was added at 60°C to 100 ml 50% ethanol; by cooling the hydro-alcoholic solution, 4.5 grams of 2-bis(β- hydroxyethyl)amino-4,5-diphenyl-oxazole was obtained (yield, 69.5%). The product crystallized from ethyl ether + petroleum ether, with a MP of 96 to 98°C.

• Therapeutic Function

  Antiinflammatory

• Handelsname

  Ageroplas (Lepori, Spain; Serono, Italy), Fendazol (Lepori, Portugal).

• Mechanism of action

  Ditazole is an anti-inflammatory analgesic agent that is of interest primarily for its ability to inhibit platelet aggregation. For example, it normalizes the enhanced platelet activity in cerebrovascular patients suffering transient ischemic attacks.

• Synthese

  ditazole is prepared by heating 2- chloro-4,5-diphenyloxazole and diethanolamine in ethanol.
  

ditazole Upstream-Materialien And Downstream Produkte

Ditazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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