2,5-Diphenyloxazol

Bezeichnung:2,5-Diphenyloxazol

CAS-Nr92-71-7

Englisch Name:2,5-Diphenyloxazole

CBNumberCB3693821

SummenformelC15H11NO

Molgewicht221.25

MOL-Datei92-71-7.mol

Synonyma

2,5-Diphenyloxazol

2,5-Diphenyloxazol physikalisch-chemischer Eigenschaften

Schmelzpunkt	72-74 °C(lit.)
Siedepunkt	360 °C(lit.)
Dichte	1.06
Dampfdruck	0.002Pa at 25℃
Brechungsindex	1.6231 (estimate)
Flammpunkt	360°C
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	very faint turbidity in Methanol
pka	0.39±0.10(Predicted)
Aggregatzustand	Liquid
Farbe	White
Wasserlöslichkeit	NEGLEGIBLE
BRN	157021
Stabilität	Stable. Incompatible with strong oxidizing agents.
LogP	4.1 at 30℃ and pH5.6
CAS Datenbank	92-71-7(CAS DataBase Reference)
NIST chemische Informationen	Oxazole, 2,5-diphenyl-(92-71-7)
EPA chemische Informationen	Oxazole, 2,5-diphenyl- (92-71-7)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-36-22
S-Sätze:	24/25-25-24-36/37-26
WGK Germany	3
RTECS-Nr.	RP6825000
TSCA	Yes
HS Code	29349990

Gefahreninformationscode (GHS)

2,5-Diphenyloxazole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S25:Berührung mit den Augen vermeiden.
S24:Berührung mit der Haut vermeiden.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
light beige solid
Verwenden
PPO can be used as a dopant that improves the photo-electric feedback of plastic scintillators which are used as radiation detectors for nuclear materials. It can be coated on peptide substrates to facilitate radioactive labelling which can enable determination of substrate specificity of lysine methyltransferase enzymes. It may also be used in the fabrication of organic luminescent materials which can be used in light emitting diodes (LEDs).
Synthesis Reference(s)
Journal of the American Chemical Society, 88, p. 1844, 1966 DOI: 10.1021/ja00960a066
The Journal of Organic Chemistry, 36, p. 1937, 1971 DOI: 10.1021/jo00813a021
Allgemeine Beschreibung
2,5-Diphenyloxazole (PPO) is an oxazole that can be used as a scintillator and a laser dye. It has fluorescence at a wavelength of 375 nm. It can be used as a wavelength shifter in liquid samples due to their high quantum yield and large strokes shift.
Hazard
May cause irritation
Synthese
The synthesis of 2,5-Diphenyloxazole is as follows:
In a 5000L enamel reactor with mechanical stirring and a thermometer, add benzoylaminoacetic acid (179 kg, 1 km) and thionyl chloride (238 kg, 2 km), react at 50°C, and monitor the sample until the compound is fully reacted. Unreacted thionyl chloride is distilled off to obtain benzoylaminoacetyl chloride. Cool down to 50°C, add benzene (780 kg, 10 kmol) to the reactor andAluminum trichloride (267 kg, 2 kmol), heated to reflux for 3 hours.The obtained N-benzoyl-ω-aminoacetophenone reaction solution was cooled to 30°C, 50 wt% sulfuric acid (392 kg, 2 kmol) was added, and the temperature was slowly raised to 100°C, and the reaction was completed at this temperature. Excess benzene was distilled off, the reaction solution was cooled to 30°C, water (1568 kg) was added dropwise to the reactor, and a white solid was precipitated, filtered, and rectified to obtain 2,5-diphenyloxazole of about 202 kg. The yield was 91.4%, the content was 99.3% (HPLC).
läuterung methode
Distil it in steam and crystallise it from ligroin. [Beilstein 27 III/IV 1437.]

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