Difenacoum

Bezeichnung:Difenacoum

CAS-Nr56073-07-5

Englisch Name:Difenacoum

CBNumberCB7396883

SummenformelC31H24O3

Molgewicht444.52

MOL-Datei56073-07-5.mol

Synonyma

3-(3-Biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycumarin

Difenacoum

Difenacoum physikalisch-chemischer Eigenschaften

Schmelzpunkt	215-217°
Siedepunkt	514.5°C (rough estimate)
Dichte	1.0800 (rough estimate)
Brechungsindex	1.5500 (estimate)
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
pka	4.50±1.00(Predicted)
BRN	8360065
CAS Datenbank	56073-07-5(CAS DataBase Reference)
EPA chemische Informationen	Difenacoum (56073-07-5)

Sicherheit

Kennzeichnung gefährlicher	T+,N
R-Sätze:	28-48/25-50/53
S-Sätze:	36/37-45-60-61
RIDADR	3027
WGK Germany	3
HazardClass	6.1(a)
PackingGroup	I
Giftige Stoffe Daten	56073-07-5(Hazardous Substances Data)
Toxizität	LD50 orally in Wistar male, female rats (mg/kg): 1.8, 2.5; in male rabbits: 2.0 mg/kg; in dogs: 50 mg/kg; in cats: 100 mg/kg

Gefahreninformationscode (GHS)

Difenacoum Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R28:Sehr giftig beim Verschlucken.
R48/25:Giftig: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
Difenacoum, is also called 3-(3-biphenyl-4-yl-1,2,3,4- tetrahydro-1-naphthyl)-4-hydroxycoumarin, consists of colorless crystals which are insoluble in water, moderately to readily soluble in acetone, chloroform, ethyl acetate, benzene.Difenacoum is synthesized by the condensation of 4-hydroxycoumarin and 3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthol (49).
Verwenden
Difenacoum is a 4-hydroxycouramin derivative. Difenacoum is a second generation anticoagulant rodenticide used against rodent pests such as rats and mice.
Verwenden
Pesticide.
Definition
ChEBI: Difenacoum is a ring assembly, a member of benzenes and a member of naphthalenes.
Landwirtschaftliche Anwendung
Rodenticide: Difenacoum is an anticoagulant that is effective against rats and mice, including warfarin-resistant strains. It is used in agriculture and urban rodent control as ready-to-use baits.
Handelsname
COMPO®; MATRAK®; NEOSOREXA® PELLETS; NEOSOREXA PP580®; RASTOP®; RATAK®; RATRICK®; SILO; SOREXA GEL; STORM
Sicherheitsprofil
A poison by ingestion and skincontact. When heated to decomposition it emits acridsmoke and irritating vapors.
Toxicity evaluation
Appearing in 1974, difenacoum was the first of the new generation of anticoagulants to be commercialized for the control of rodents resistant to warfarin and related compounds (42). LD₅₀ values (acute oral) for warfarinsusceptible rodent strains are about a factor of 2 lower than for warfarin-resistant strains. There is also a degree of specificity. The compound is generally less toxic to nontarget animals than to targets. A wide range of bait types containing 0.005% difenacoum is available, including meals, broken and whole grains, pellets, and wax blocks. A 0.1% contact dust is no longer widely used. Resistance to difenacoum was detected among a population of Norway rats in the United Kingdom in 1978 (50). This remains a problem of local importance but relatively low resistance factors indicate that other behavioral factors also play a significant role (51). Difenacoum resistance has also been recorded in other European countries (39).

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