Clocortolone Struktur

Clocortolon

Bezeichnung:Clocortolon

CAS-Nr4828-27-7

Englisch Name:Clocortolone

CBNumberCB7198298

SummenformelC22H28ClFO4

Molgewicht410.91

MOL-Datei4828-27-7.mol

Synonyma

Clocortolon

Clocortolon physikalisch-chemischer Eigenschaften

Schmelzpunkt	254° (dec)
Siedepunkt	566.0±50.0 °C(Predicted)
Dichte	1.32±0.1 g/cm3(Predicted)
storage temp.	Refrigerator, Under Inert Atmosphere
Löslichkeit	Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	12.98±0.10(Predicted)
Farbe	White to Light Yellow

Clocortolone Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Clocortolone,Schering AG
Verwenden
Corticosteroid used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.
Verwenden
Clocortolone can be used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.
Definition
ChEBI: Clocortolone is 16alpha-Methylpregna-1,4-diene-3,20-dione bearing hydroxy substituents at the 11beta and 21 positions, fluorine at position 6 and chlorine at position 9. A medium potency corticosteroid, it is used as its 21-O-pivalate or caproate ester for the relief of inflammatory and pruritic (itching) skin disorders. It has a role as an anti-inflammatory drug and an antipruritic drug. It is a glucocorticoid, an 11beta-hydroxy steroid, a 21-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid, a chlorinated steroid and a primary alpha-hydroxy ketone.
Manufacturing Process
6α-Fluoro-16α-methyl-21-hydroxy-1,4,9(11)-pregnatriene-3,20-dione is suspended in nitroethane at heating. To this suspension 1 N perchloric acid is added and then t-butyl hypochlorite is added dropwise. The reaction mixture is agitated at heating, then cooled to room temperature, mixed with methanol, stirred and then poured with water containing ice. The mixture is then stirred, thus precipitated product is filtered, washed neutral with water, dried; The crude product is treated with hot methanol, and recrystallized from ethanol, thus 9α-chloro-6α-fluoro-11β,21-dihydroxy-16α-methyl-1,4- pregnadiene-3,20-dione was obtained.
Therapeutic Function
Glucocorticoid

Clocortolone Upstream-Materialien And Downstream Produkte

Clocortolon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4828-27-7, Clocortolone Verwandte Suche:

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