1-EBIO Struktur

1-Ethylbenzimidazolin-2-on

Bezeichnung:1-Ethylbenzimidazolin-2-on

CAS-Nr10045-45-1

Englisch Name:1-EBIO

CBNumberCB7146587

SummenformelC9H10N2O

Molgewicht162.19

MOL-Datei10045-45-1.mol

Synonyma

1-Ethylbenzimidazolin-2-on

1-Ethylbenzimidazolin-2-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	118-120 °C(Solv: ethyl acetate (141-78-6))
Dichte	1.161±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO: ≥20mg/mL
Aggregatzustand	powder
pka	12.29±0.30(Predicted)
Farbe	Crystalline
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36
S-Sätze:	26
WGK Germany	3
HazardClass	IRRITANT
HS Code	2933998090

Gefahreninformationscode (GHS)

1-EBIO Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 μM in T84 human carcinoma cells).This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 μM).1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.
Verwenden
1-EBIO stimulates Cl- secretion in secretory epithelia through direct activation of clacium potassium channels.
1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.
The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients
Definition
ChEBI: 1-Ethyl-2-benzimidazolinone is a member of imidazoles.
Biologische Aktivität
Activator of epithelial K Ca channels, stimulates a large and sustained trans-epithelial Cl - secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells.
Lager
Room temperature
Einzelnachweise
1) Adeagbo?et al.?(1999),?1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol.,?379?151 2) Orfila?et al. (2014),?Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci.,?40?3179 3) Allen?et al.?(2011),?SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab.,?31?2302 4) Muller?et al. (2012),?Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev.,?8?720 5) Fay?et al.?(2006),?SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA,?103?17548

1-EBIO Upstream-Materialien And Downstream Produkte

1-Ethylbenzimidazolin-2-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

10045-45-1, 1-EBIO Verwandte Suche:

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