Oxatomid

Bezeichnung:Oxatomid

CAS-Nr60607-34-3

Englisch Name:Oxatomide

CBNumberCB3210840

SummenformelC27H30N4O

Molgewicht426.55

MOL-Datei60607-34-3.mol

Synonyma

Oxatomid

Oxatomid physikalisch-chemischer Eigenschaften

Schmelzpunkt	153.60C
Siedepunkt	541.98°C (rough estimate)
Dichte	1.1239 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	Refrigerator
Löslichkeit	DMSO: soluble
Aggregatzustand	White solid.
pka	12.20±0.30(Predicted)
Farbe	white
CAS Datenbank	60607-34-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	DE2276000
Toxizität	LD50 in guinea pigs, mice, rats (mg/kg): 320, >2560, >2560 orally; 23, 27, 30 i.v. (Richards)

Gefahreninformationscode (GHS)

Oxatomide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Powder
Originator
Tinset,Janssen,W. Germany ,1981
Verwenden
Orally active anti-allergic agent; related structurally to cinnarizine and having a novel biphasic mode of action.
Verwenden
Inhibits the release and actions of leukotrienes
Definition
ChEBI: Oxatomide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug. It has a role as a geroprotector, a H1-receptor antagonist, an anti-allergic agent, an anti-inflammatory agent and a serotonergic antagonist. It is a N-alkylpiperazine, a member of benzimidazoles and a diarylmethane.
Manufacturing Process
A mixture of 53 parts of 1-(3chloropropyl)-2H-benzimidazol-2one, 5 parts of 1-(diphenylmethyl)piperazine, 6.4 parts of sodium bicarbonate and 200 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with waterseparator. After cooling, water is added and the layers are separated. The 4methyl-2pentanone phase is dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and 5% of methanol as eluent. The pure fractions are collected and the eluent is evaporated. The oily residue is crystallized from a mixture of 2,2'-oxybispropane and a small amount of 2-propanol. The product is filtered off and dried, yielding 1-[3-[4-(diphenylmethyl)-1piperazinyl]propyl]-2H-benzimidazole-2-one; melting point 153.6°C.
Therapeutic Function
Antiallergic
Sicherheitsprofil
Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Used to treat allergies and asthma. When heated to decomposition it emits toxic fumes of NOx.
Synthese
Oxatomide is synthesized by alkylation of 1-diphenylmethylpiperazine with 1-(3-chloropropyl)-1,3-dihydro-2Hbenzimidazol- 2-one in the presence of Na2CO3 . In addition to its histamine H1 receptor antagonistic effect, oxatomide may have mast-cell stabilizing activities .

Oxatomide Upstream-Materialien And Downstream Produkte

Oxatomid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

60607-34-3, Oxatomide Verwandte Suche:

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