5-Iodo-6-methyl-pyridin-2-ylamine

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H301：Giftig bei Verschlucken.

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P405：Unter Verschluss aufbewahren.

5-Iodo-6-methyl-pyridin-2-ylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  1824-81-3

  

  75073-11-9

  The general procedure for the synthesis of 2-amino-5-iodo-6-methylpyridine from 2-amino-6-methylpyridine is as follows: a mixture of 2-amino-6-methylpyridine (5.40 g), periodic acid (2.28 g), and iodine (5.00 g) was dissolved in a mixture of acetic acid (30 mL), water (6 mL), and sulfuric acid (0.9 mL), and heated to a reaction temperature of 80°C for 3 hr. . After the reaction was completed, the mixture was cooled to room temperature and slowly poured into 100 mL of 10% aqueous sodium bisulfite solution. The aqueous phase was extracted with ether (3 x 100 mL) and the organic phase was combined. The organic phase was washed sequentially with 10% sodium hydroxide solution, dried over anhydrous sodium sulfate, filtered and concentrated. Purification by column chromatography (eluent: ethyl acetate) gave a yellow liquid product. The liquid was further dried under a vacuum pump to induce crystallization to finally obtain 2-amino-5-iodo-6-methylpyridine (4.48 g, 38% yield). The physical properties of the product were as follows: 1H NMR (300 MHz, DMSO-d6) δ 7.60,6.09,6.05,2.38.

• Einzelnachweise

  [1] Patent: WO2014/39484, 2014, A1. Location in patent: Page/Page column 50
  [2] Journal of Medicinal Chemistry, 2007, vol. 50, # 25, p. 6383 - 6391
  [3] Patent: US2002/7066, 2002, A1
  [4] Tetrahedron Letters, 2001, vol. 42, # 23, p. 3795 - 3797
  [5] Tetrahedron Letters, 2003, vol. 44, # 14, p. 2971 - 2973

5-Iodo-6-methyl-pyridin-2-ylamine Upstream-Materialien And Downstream Produkte

5-Iodo-6-methyl-pyridin-2-ylamine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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