4,4'-Bis(hydroxymethyl)biphenyl

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H304：Kann bei Verschlucken und Eindringen in die Atemwege tödlich sein.

  H332：Gesundheitsschädlich bei Einatmen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

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  P331：KEIN Erbrechen herbeiführen.

  P403：An einem gut belüfteten Ort aufbewahren.

4,4'-Bis(hydroxymethyl)biphenyl Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White crystalline powder

• Synthese

  

  792-74-5

  

  1667-12-5

  a) Preparation of 4,4'-bis(hydroxy-methyl)biphenyl. In a 2-liter flask equipped with a mechanical stirrer, condenser, addition funnel and heating bath, 789 mg (20.8 mmol) of LiAlH4 was dissolved in 150 ml of anhydrous THF (tetrahydrofuran). A solution of 7.5 g (27.7 mmol) of 4,4'-bis(methoxycarbonyl)biphenyl dissolved in 500 ml of anhydrous THF was heated to 50 °C under an inert atmosphere and added dropwise to the above mixture over 1 hour. After the dropwise addition, stirring was continued at 50 °C for 30 minutes. Subsequently, the reaction mixture was cooled to room temperature and 15 ml of THF/H2O (80:20) mixture was carefully added to quench the excess LiAlH4. The reaction mixture was filtered through a Septum G2 filter and the precipitate was washed with ethanol (3 x 100 ml). The filtrate and washings were combined and evaporated to dryness under vacuum in a heating bath at 40 °C. The residue was redissolved in 100 ml of hot acetone (50 °C), filtered to remove insoluble matter, dried with anhydrous Na2SO4 and evaporated again to dryness. Finally 5.74 g of 4,4'-bis(hydroxymethyl)biphenyl was obtained in 96.6% molar yield.

• Einzelnachweise

  [1] Patent: EP469682, 1992, A1
  [2] Russian Journal of Organic Chemistry, 2008, vol. 44, # 8, p. 1172 - 1179
  [3] Chemical Physics Letters, 2008, vol. 460, # 4-6, p. 474 - 477

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