Asiaticoside

Bezeichnung:Asiaticoside

CAS-Nr16830-15-2

Englisch Name:Asiaticoside

CBNumberCB7109339

SummenformelC48H78O19

Molgewicht959.12

MOL-Datei16830-15-2.mol

Asiaticoside physikalisch-chemischer Eigenschaften

Schmelzpunkt	235-238°C
alpha	D20 -14° (alc)
Siedepunkt	1017.5±65.0 °C(Predicted)
Dichte	1.44±0.1 g/cm3(Predicted)
Dampfdruck	0.001Pa at 160℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit	DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Methanol (Slightly)
pka	12.50±0.70(Predicted)
Aggregatzustand	Solid
Farbe	Crystals
Wasserlöslichkeit	99mg/L
InChIKey	WYQVAPGDARQUBT-KRQXBQLUNA-N
LogP	0.44 at 22℃
CAS Datenbank	16830-15-2(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
RTECS-Nr.	YU9625000
F	1-10
HS Code	29389090

Asiaticoside Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Asiaticoside is the main saponin constituent of C. asiatica, a plant long used in the Ayurvedic system of medicine to treat a variety of ailments including dermatitis, diabetes, cough, cataract, hypertension, as well as for wound healing and improving memory. In various wound healing models, topical application (0.2-0.4%), injection (1 mg), or ingestion (1 mg/kg) of asiaticoside has been shown to increase hydroxyproline content, improve tensile strength, increase collagen synthesis and remodeling of the collagen matrix, promote epithelialization, stimulate glycosaminoglycan synthesis, and elevate antioxidant levels.
Chemische Eigenschaften
White powder
Verwenden
Asiatic Acid is a terpenoid saponin component isolated from Centella asiatica with antioxidant and anti-inflammatory activities. Asiaticoside has been shown to possess strong wound-healing properties and reduces scar formation.
Verwenden
wound healing, anxiolytic
Definition
ChEBI: Asiaticoside is a triterpenoid saponin.
Flammability and Explosibility
Not classified
Biologische Aktivität
Asiaticoside, a triterpenoid compound from Centella asiatica, has been shown to have anti-inflammatory, anti-renal fibrosis and tissue repair promoting effects. Asiaticoside has been shown through ex vivo and in vivo studies to reduce blood urea nitrogen (BUN) and serum creatinine (Scr) levels in a renal ischemia-reperfusion injury (IRI) model^[1]. Meanwhile, Asiaticoside decreased the secretion of IL-6, IL-1β, and TNF-α, but increased the secretion of IL-10 using a dose-dependent manner. Treatment of Raw264.7 cells with lipopolysaccharide (LPS) induced an inflammatory response, but the LPS-induced effect was attenuated by the administration of asiaticoside. In addition, asiaticoside significantly inhibits LPS-induced expression of inducible nitric oxide synthase (iNOS) and promotes expression of the polarisation marker protein arginase 1. It is also a potential candidate for use as a dental wound healing agent with a maximum tolerated concentration of 0.25 mg/ml, and its mechanism of action may be related to increased Col1A1 gene expression ^[2].
Sicherheitsprofil
Questionable carcinogen withexperimental tumorigenic data. When heated todecomposition it emits acrid smoke and fumes. Promoteshealing of wounds.
Lager
+4°C
Einzelnachweise
[1] XINGYING ZHAO, JINGWEN ZHOU*; Elucidation of the Biosynthesis of Asiaticoside and Its Reconstitution in Yeast[J]. ACS Sustainable Chemistry & Engineering, 2024, 12 10: 4028-4040. DOI:10.1021/acssuschemeng.3c07046.
[2] W. H. SURIYAH. In Vitro Wound Healing Effect of Asiaticoside Extracted from Centella asiatica (‘Pegaga’) on Human Gingival Fibroblast Cell Line[J]. Materials Science Forum, 2021, 72 1: 224-229. DOI:10.4028/www.scientific.net/MSF.1025.224.

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