Decamethoniumbromid

Bezeichnung:Decamethoniumbromid

CAS-Nr541-22-0

Englisch Name:DECAMETHONIUM BROMIDE

CBNumberCB6360047

SummenformelC16H38Br2N2

Molgewicht418.29

MOL-Datei541-22-0.mol

Synonyma

Decamethoniumbromid

Decamethoniumbromid physikalisch-chemischer Eigenschaften

Schmelzpunkt	263-267 °C(lit.)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	DMF: 2 mg/ml; DMSO: 16 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 5 mg/ml
Aggregatzustand	crystalline
Farbe	off-white
Wasserlöslichkeit	almost transparency
maximale Wellenlänge (λmax)	λ: 240 nm Amax: 0.04 λ: 250 nm Amax: 0.03 λ: 260 nm Amax: 0.02 λ: 500 nm Amax: 0.02
Merck	14,2847
BRN	3728288
Stabilität	Stable. Incompatible with strong oxidizing agents.
CAS Datenbank	541-22-0(CAS DataBase Reference)
EPA chemische Informationen	Decamethonium dibromide (541-22-0)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-36/37/38
S-Sätze:	26-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	BP5950000
F	3-10
HS Code	2923.90.0100
HazardClass	6.1(b)
PackingGroup	III
Toxizität	LD50 oral in mouse: 190mg/kg

Gefahreninformationscode (GHS)

DECAMETHONIUM BROMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Decamethonium is a depolarizing neuromuscular blocking agent. It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs). Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC₅₀ value of 40 μM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC₅₀ values of 7.4, 405, 28, and 59 μM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC₅₀ = 52 μM for the human receptor). It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED₉₅ values of 35 and 70 μg/kg for cats under chloralose and ether anesthesia, respectively. Formulations containing decamethonium have been used to induce paralysis during anesthesia.
Chemische Eigenschaften
crystalline solid
Verwenden
antipsychotic
Trademarks
Syncurine (GlaxoSmithKline).
Biologische Funktion
Decamethonium was one of the first neuromuscular blocking agents to be synthesized. An SAR study on a series of bis-quaternary ammonium compounds with varying numbers of methylene groups separating the nitrogen atoms demonstrated that maximal neuromuscular blockade occurred with 10 to 12 unsubstituted methylene groups. Activity diminished as the number of carbons was either decreased or increased. The compound with six methylene groups, hexamethonium, is a nicotinic antagonist at autonomic ganglia (ganglionic blocking agent). All the compounds in this series that possessed neuromuscular blocking activity also caused depolarization of the postjunctional membrane.
Allgemeine Beschreibung
Crystals derived from methanol and acetone.
Air & Water Reaktionen
Water soluble.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition DECAMETHONIUM BROMIDE emits very toxic fumes.
Brandgefahr
Flash point data for DECAMETHONIUM BROMIDE are not available. DECAMETHONIUM BROMIDE is probably combustible.

Decamethoniumbromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

541-22-0, DECAMETHONIUM BROMIDE Verwandte Suche:

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