4,9-Diazadodecamethylendiamin

Bezeichnung:4,9-Diazadodecamethylendiamin

CAS-Nr71-44-3

Englisch Name:Spermine

CBNumberCB6275334

SummenformelC10H26N4

Molgewicht202.34

MOL-Datei71-44-3.mol

Synonyma

4,9-Diazadodecamethylendiamin

4,9-Diazadodecamethylendiamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	28-30 (lit.)
Siedepunkt	150 °C/5 mmHg (lit.)
Dichte	0.937
Brechungsindex	1.4850 (estimate)
Flammpunkt	>230 °F
storage temp.	2-8°C
Löslichkeit	H₂O: 1 M at 20 °C, clear, colorless
Aggregatzustand	powder
pka	10.88±0.19(Predicted)
Wasserlöslichkeit	Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether.
Sensitive	Air Sensitive & Hygroscopic
Merck	14,8743
BRN	1751791
Stabilität	Hygroscopic
InChIKey	PFNFFQXMRSDOHW-UHFFFAOYSA-N
LogP	-0.543 (est)
CAS Datenbank	71-44-3(CAS DataBase Reference)
NIST chemische Informationen	Spermine(71-44-3)
EPA chemische Informationen	1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3)

Sicherheit

Kennzeichnung gefährlicher	Xi,C
R-Sätze:	36/38-34
S-Sätze:	26-36-45-36/37/39-27
RIDADR	UN 3259 8/PG 2
WGK Germany	3
RTECS-Nr.	EJ7230000
F	3-10
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29212900

Gefahreninformationscode (GHS)

Spermine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/38:Reizt die Augen und die Haut.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
Beschreibung
Spermine is an endogenous polyamine synthesized from the reaction of spermidine with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K⁺ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.
Chemische Eigenschaften
White to slightly off-white powder crysta
Verwenden
immune modulator
Verwenden
Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes
Verwenden
Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).
Definition
ChEBI: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.
Allgemeine Beschreibung
Spermine?is a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation.
Biochem/physiol Actions
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Lager
+4°C (desiccate)
Einzelnachweise
[1] fakler b, brndle u, glowatzki e, et al. strong voltage-dependent inward rectification of inward rectifier k+ channels is caused by intracellular spermine[j]. cell, 1995, 80(1): 149-154.
[2] til h p, falke h e, prinsen m k, et al. acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats[j]. food and chemical toxicology, 1997, 35(3): 337-348.

Spermine Upstream-Materialien And Downstream Produkte

4,9-Diazadodecamethylendiamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

71-44-3, Spermine Verwandte Suche:

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