21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat Produkt Beschreibung

Clobetasol propionate Struktur
25122-46-7
  • CAS-Nr.25122-46-7
  • Bezeichnung:21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat
  • Englisch Name:Clobetasol propionate
  • Synonyma:21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat
    Olux;Psorex;Olux-E;Clobex;cgp9555;GR-2/92;Karison;Temovate;CCl 4725;Dermoval
  • CBNumber:CB6274337
  • Summenformel:C25H32ClFO5
  • Molgewicht:466.97
  • MOL-Datei:25122-46-7.mol
21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :195.5-1970C
  • Siedepunkt: :569.0±50.0 °C(Predicted)
  • alpha  :D +103.8° (c = 1.04 in dioxane)
  • Dichte :1.1653 (estimate)
  • storage temp.  :Keep in dark place,Sealed in dry,2-8°C
  • Löslichkeit :Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent).
  • Aggregatzustand :neat
  • pka :12.88±0.70(Predicted)
  • InChIKey :CBGUOGMQLZIXBE-XGQKBEPLSA-N
  • CAS Datenbank :25122-46-7(CAS DataBase Reference)
Sicherheit

Clobetasol propionate Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Chemische Eigenschaften White or almost white, crystalline powder.
  • Originator Dermovate,Glaxo,UK,1973
  • Verwenden For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
  • Verwenden Topical corticosteroid. Glucocorticoid; anti-inflammatory.
    Clobetasol Propionate
    Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.
  • Verwenden Clobetasol-17-propionate is a topical corticosteroid belonging to the group-D (hydrocortisone-q-butyrate) type of steroids.
  • Indications Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.
  • Definition ChEBI: The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.
  • Manufacturing Process A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide (25 ml) was treated with lithium chloride (4 g) and the mixture heated on the steam bath for 30 minutes. Dilution with water gave the crude product which was recrystallized to afford the title compound, MP 226°C.
    Clobetasol is usually converted to the propionate as the useful form by reaction with propionic anhydride.
  • Trademarks Clobex (Galderma); Clobex (Galderma); Embeline (Healthpoint); Olux (Connetics); Temovate (Altana).
  • Therapeutic Function Corticosteroid, Antiinflammatory
Clobetasol propionate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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25122-46-7, Clobetasol propionate Verwandte Suche:
  • 17-propionate
  • cgp9555
  • Clobetasol 17- propionate solution,100ppm
  • Cloβsol propionate
  • 21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate
  • CLOBETASOL 17-PROPIONATE USP
  • [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
  • Dermovate
  • GR-2/92
  • Olux
  • Psorex
  • Temovate
  • CLOBETASOLPROPIONATE,MICRONIZED
  • CLOBETASOLPROPIONATE,MICRONIZED,USP
  • 21-Chloro-21-deoxybetamethasone 17-propionate
  • CCl 4725
  • Clobederm
  • Dermoval
  • Dermoxinale
  • GR 2/925
  • Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-
  • Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methyl-, 17-propionate (8CI)
  • 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione=17-propionate
  • 21-Chloro-9α-fluoro-11β-hydroxy-16β-methyl-17α-propionyloxy-1,4-pregnadiene-3,20-dione
  • Propionic acid clobetasol
  • Clobetasol Propionate (200 mg)
  • 21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-d
  • propanoic acid [(9R,17R)-17-(2-chloro-1-oxoethyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
  • clobesol
  • pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-me
  • CLOBESTASOL PROPIONATE
  • CLOBETASOL-17-PROPIONATE
  • CLOBETASOLE PROPIONATE
  • CLOBETASOL PROPIONATE
  • 21-chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
  • Pregna-1,4-Diene-3,20-Dione,21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-17-(1-Oxopropoxy)-,(11Beta,16Beta)-
  • Clobetasolpropionatmikron.
  • Karison
  • Olux-E
  • Skin Cap
  • (11β,16β)-21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
  • 21-Chloro-9-fluoro-11b
  • Clobetasol Propionate (200 mg)F2C309980ug/mg(ai)
  • Clobetasol Propionate-d5
  • 21-Chloro-9alpha-fluoro-11beta,17alpha-dihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17-Propionate
  • Clobex
  • Clobetasol Propionate 25122-46-7
  • Skin Disease Corticosteroids Raw Powder Clobetasol Propionate 25122-46-7
  • Clobetasol propionate CRS
  • Clobetasol Propionate RS
  • Cloβsol17-Propionate&gt
  • Clobetasol for peak identification CRS
  • obetasoL
  • 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-Methylpregn-4-ene-3,20-dione 17-Propionate
  • Clobetasol-[d5] 17-propionate
  • Clobetasol propionate USP/EP/BP
  • Clobetazole propionate
  • 25122-46-7