21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat

Bezeichnung:21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat

CAS-Nr25122-46-7

Englisch Name:Clobetasol propionate

CBNumberCB6274337

SummenformelC25H32ClFO5

Molgewicht466.97

MOL-Datei25122-46-7.mol

Synonyma

21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat

21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat physikalisch-chemischer Eigenschaften

Schmelzpunkt	195.5-1970C
alpha	D +103.8° (c = 1.04 in dioxane)
Siedepunkt	569.0±50.0 °C(Predicted)
Dichte	1.1653 (estimate)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
Löslichkeit	Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent).
pka	12.88±0.70(Predicted)
InChIKey	CBGUOGMQLZIXBE-XGQKBEPLSA-N
SMILES	O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC \|&1:1,2,4,6,16,18,20,23,r\|
CAS Datenbank	25122-46-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,T
R-Sätze:	36/37/38-62-53-48/20/21-61
S-Sätze:	26-36-45-36/37-53
WGK Germany	2
RTECS-Nr.	TU3725000
HS Code	29372290

Gefahreninformationscode (GHS)

Clobetasol propionate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or almost white, crystalline powder.
Originator
Dermovate,Glaxo,UK,1973
Verwenden
Clobetasol-17-propionate is a topical corticosteroid belonging to the group-D (hydrocortisone-q-butyrate) type of steroids.
Verwenden
For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Verwenden
Topical corticosteroid. Glucocorticoid; anti-inflammatory.

Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.
Indications
Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.
Definition
ChEBI: The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.
Manufacturing Process
A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide (25 ml) was treated with lithium chloride (4 g) and the mixture heated on the steam bath for 30 minutes. Dilution with water gave the crude product which was recrystallized to afford the title compound, MP 226°C.
Clobetasol is usually converted to the propionate as the useful form by reaction with propionic anhydride.
Trademarks
Clobex (Galderma); Clobex (Galderma); Embeline (Healthpoint); Olux (Connetics); Temovate (Altana).
Therapeutic Function
Corticosteroid, Antiinflammatory

Clobetasol propionate Upstream-Materialien And Downstream Produkte

21-Chlor-9-fluor-11β,17-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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