Neotuberostemonine

Neotuberostemonine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruitment and M2 polarization of macrophages. Neotuberostemonine demonstrates antitussive properties in guinea pigs.

• Verwenden

  Neotuberostemonine is a major bioactive alkaloid of Stemona tuberosa. It can also be used to treat pulmonary fibrosis.

• Definition

  ChEBI: Neotuberostemonine is an alkaloid. It has a role as a metabolite.

• Biologische Funktion

  Neotuberostemonine is an alkaloid originally isolated from S. tuberosa that has diverse biological activities. It inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at a concentration of 100 μM. Neotuberostemonine (50 μM) inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells. It reduces the citric acid-induced cough reflex in conscious guinea pigs when administered at a dose of 133 μmol/kg. Neotuberostemonine (40 mg/kg) inhibits pulmonary collagen deposition and fibrosis, as well as bronchoalveolar lavage fluid (BALF) monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis.

• Biologische Aktivität

  Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages.

Neotuberostemonine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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