(+)-FANGCHINOLINE

Bezeichnung:(+)-FANGCHINOLINE

CAS-Nr436-77-1

Englisch Name:(+)-FANGCHINOLINE

CBNumberCB6221346

SummenformelC37H40N2O6

Molgewicht608.72

MOL-Datei436-77-1.mol

(+)-FANGCHINOLINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	240～242℃
Siedepunkt	709.7±60.0 °C(Predicted)
Dichte	1.204±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
Löslichkeit	Soluble in chloroform and methanol;
pka	9.38±0.20(Predicted)
Aggregatzustand	powder to crystal
Farbe	White to Orange to Green
Wasserlöslichkeit	slightly soluble in water

Sicherheit

HS Code

2939.79.0000

Gefahreninformationscode (GHS)

(+)-FANGCHINOLINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Fangchinoline is an alkaloid that has been found in S. tetrandrae and has diverse biological activities, including anti-inflammatory, neuroprotective, and anticancer properties. It inhibits the activity of sheep COX and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells with IC₅₀ values of 129 and 3.7 μM, respectively. Fangchinoline (1 and 10 μM) reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons. It decreases proliferation of PC3 human prostate cancer cells by 63 and 86% when used at concentrations of 20 and 30 μM, respectively. Fangchinoline reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 5 mg/kg per day for 12 days.
Beschreibung
A bisbenzylisoquino!ine alkaloid obtained from Limacia cuspidata (Miers.) Hook. f. et Thorn., the base crystallizes from Me2CO in the form of long, colourless needles. It is strongly laevorotatory with [α]_D - 2120 (CHCI3) and has been shown to be the optical antipode of fanchinoline (q.v.).
Verwenden
(+)-Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication.
Definition
ChEBI: A bisbenzylisoquinoline alkaloid that is (1beta)- berbaman which has been substituted by methyl groups at the 2 and 2' positions, by methoxy groups at the 6, 6', and 12 positions, and by a hydroxy group at position 7. Isolated from S ephania tetrandra, it has been found to possess neuroprotective and anti-tumour activity.
Einzelnachweise
Tomita, Furukawa., Tetrahedron Lett., 4293 (1966)

(+)-FANGCHINOLINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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