Guanoclor

guanoclor Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Vatensol,Pfizer

• Verwenden

  Antihypertensive.

• Verwenden

  Guanochlorine is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes.

• Definition

  ChEBI: Guanoclor is a dichlorobenzene.

• Manufacturing Process

  20 parts by weight of 2-(2,6-dichlorophenoxy)ethyl bromide dissolved in 75 parts by volume of ethanol are slowly added with stirring to 37 parts by weight of hydrazine hydrate in 25 parts by volume of ethanol. The mixture is boiled under reflux conditions for 16 h. The solvent and excess hydrazine are removed by distillation under reduced pressure. Water and excess solid sodium hydroxide are added to make the mixture alkaline. The mixture is extracted with chloroform, dried over anhydrous potassium carbonate, filtered and freed from solvent by distillation. The residual oil is distilled at 1 mm of mercury pressure. The fraction boiling at 132° to 140°C and consists of 2- (2,6-dichlorophenoxy)ethyl hydrazine.
  23 parts by weight of 2-(2,6-dichlorophenoxy)ethyl hydrazine and 14.46 parts by weight of S-methylisothiouronium sulfate in 150 parts by volume of water are boiled together under reflux conditions for 4 h. The solid which precipitates on cooling is recrystallized from water and consists of 14.5 parts by weight of N-[2-(2,6-dichlorophenoxy)ethylamino]guanidine hydrogen sulfate having a melting point of 214°C.

• Trademarks

  Vatensol (Pfizer).

• Therapeutic Function

  Antihypertensive

guanoclor Upstream-Materialien And Downstream Produkte

Guanoclor Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(42)Suppliers

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