Lithiumamid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H261：In Berührung mit Wasser entstehen entzündbare Gase.

  H314：Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

• Sicherheit

  P223：Keinen Kontakt mit Wasser zulassen.

  P231+P232：Unter inertem Gas handhaben. Vor Feuchtigkeit schützen.

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Lithium amide Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R14/15:Reagiert heftig mit Wasser unter Bildung hochentzündlicher Gase.
  R29:Entwickelt bei Berührung mit Wasser giftige Gase.
  R34:Verursacht Verätzungen.
  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
  R15:Reagiert mit Wasser unter Bildung hochentzündlicher Gase.
  R14:Reagiert heftig mit Wasser.
  R11:Leichtentzündlich.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S43:Zum Löschen . . . (vom Hersteller anzugeben) verwenden (wenn Wasser die Gefahr erhöht, anfügen: "Kein Wasser verwenden").
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S7/8:Behälter trocken und dicht geschlossen halten.
  S16:Von Zündquellen fernhalten - Nicht rauchen.

• Chemische Eigenschaften

  white to grey fine powder

• Physikalische Eigenschaften

  Colorless needles; tetragonal structure; density 1.178 g/cm³ at 17.5°C; melts around 375°C; starts to decompose at 320°C; decomposes at 400°C; soluble in cold water; decomposes in hot water; slightly soluble in ethanol and liquid ammonia; insoluble in benzene and ether.

• Verwenden

  Reagent for synthesis of: Antiinflamatory and preoresolving protectin D11 Chemotype dipeptidyl peptidase IV inhibitors2 Sterically congested triarylamines3 Dyes displaying large Stokes shifts4 GM1 ganglioside derivatives5Reagent for cross-coupling of aryl chlorides and amines6

• Verwenden

  Lithium amide is used in the preparation of active pharmaceutical ingredients and antioxidants. It acts as a catalyst for polymers, as nucleophiles and as strong bases. It serves as a reagent in the synthesis of antiinflamatory and preoresolving protectin D1, chemotype dipeptidyl peptidase IV inhibitors and sterically congested triarylamines. It finds application in dyes displaying large stokes shifts. In addition to this, it is used as a reagent for cross-coupling of aryl chlorides and amine.

• Verwenden

  In Claisen condensations, alkylation of nitriles and ketones, synthesis of ethynyl Compounds, acetylenic carbinols.

• synthetische

  Lithium amide, LiNH2 , may be considered the ammonia analogue of lithium hydroxide in the water system. Lithium amide may be prepared from lithium hydride or lithium metal and ammonia. Industrial preparations use lithium hydride as a starting material.
  The reaction of lithium metal in a stream of ammonia gas at about 400°C may be used successfully as a preparative method. Lithium may also be reacted with liquid ammonia in the presence of an iron compound as a catalyst.
  Since amide ion is the strongest base which can exist in ammonia, lithium amide is a very strong base. The compound has a low solubility in liquid ammonia. Lithium amide is hydrolyzed by water to yield lithium hydroxide and ammonia. It is readily oxidized. For example, the substance may be oxidized with dinitrogen oxide to yield lithium azide. Amides of the alkali metals in general must be guarded against air oxidation to prevent the formation of potentially explosive substances.

• Allgemeine Beschreibung

  White crystalline powder with an odor of ammonia. Denser than water.

• Reaktivität anzeigen

  Powdered Lithium amide is highly reactive. A strong base. Reacts to release toxic ammonia gas with water. Forms explosive peroxide on storage.

• Health Hazard

  Highly toxic: contact with water produces toxic gas, may be fatal if inhaled. Inhalation or contact with vapors, substance or decomposition products may cause severe injury or death. May produce corrosive solutions on contact with water. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.

• Brandgefahr

  Produce flammable and toxic gases on contact with water. May ignite on contact with water or moist air. Some react vigorously or explosively on contact with water. May be ignited by heat, sparks or flames. May re-ignite after fire is extinguished. Some are transported in highly flammable liquids. Containers may explode when heated. Runoff may create fire or explosion hazard.

• Flammability and Explosibility

  Substances and mixtures which in contact with water emit flammable gases

• Sicherheitsprofil

  A powerful irritant to skin, eyes, and mucous membranes. Flammable when exposed to heat or flame. Ammonia is liberated and lithmm hydroxide is formed when this compound is exposed to moisture. Reacts violently with water or steam to produce toxic and flammable vapors. Vigorous reaction with oxilzing materials. Exothermic reaction with acid or acid fumes. When heated to decomposition it emits very toxic fumes of LiO, NH3, and NO,. Used in synthesis of drugs, vitamins, steroids, and other organics. See also LITHIUM COMPOUNDS, AMIDES, AMMONIA, and LITHIUM HYDROXIDE.

• läuterung methode

  Purify it by heating at 400o while NH3 is passed over it in the upper of two crucibles (the upper crucible is perforated). The LiNH2 will drip into the lower crucible through the holes in the upper crucible. The product is cooled in a stream of NH3. Protect it from air and moisture, store it under N2 in a clear glass bottle sealed with paraffin. Store it in small quantities so that all the material is used once the bottle is opened. If the colour of the amide is yellow, it should be destroyed as it is likely to have oxidised and to EXPLODE. On heating above 450o it is decomposed to Li2NH, which is stable up to 750-800o. [Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 463 1963, Greenlee & Henne Inorg Synth II 135 1953.]

Lithium amide Upstream-Materialien And Downstream Produkte

Lithiumamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(166)Suppliers

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