Mechitazin

Bezeichnung:Mechitazin

CAS-Nr29216-28-2

Englisch Name:MEQUITAZINE

CBNumberCB5487473

SummenformelC20H22N2S

Molgewicht322.47

MOL-Datei29216-28-2.mol

Synonyma

Mechitazin

Mechitazin physikalisch-chemischer Eigenschaften

Schmelzpunkt	143-145°C
Siedepunkt	469.4±24.0 °C(Predicted)
Dichte	1.1330 (rough estimate)
Brechungsindex	1.5800 (estimate)
storage temp.	Refrigerator
Wasserlöslichkeit	Insoluble in water
Löslichkeit	DMSO : 16 mg/mL (49.62 mM)
Aggregatzustand	powder to crystal
pka	10.43±0.33(Predicted)
Farbe	White to Almost white
Merck	14,5864
CAS Datenbank	29216-28-2(CAS DataBase Reference)
NIST chemische Informationen	Mequitazine(29216-28-2)

Sicherheit

RIDADR	UN 2811 6.1/PG III
RTECS-Nr.	SP5080000
HazardClass	6.1
PackingGroup	III
HS Code	29349990

Gefahreninformationscode (GHS)

MEQUITAZINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White Solid
Originator
Primalan,Berk,UK,1976
Verwenden
It is an antihistamine
Definition
ChEBI: Mequitazine is a member of phenothiazines.
Manufacturing Process
30 g of phenothiazine were added, all at once, to a suspension of 6 g of sodium amide in 240 ml of anhydrous xylene. The mixture was agitated and heated to reflux. When evolution of ammonia ceased (5 hours), 15 g of 3- chloromethyl-quinuclidine hydrochloride were added portionwise over a period of 50 minutes and reflux was then maintained for 22 hours. After cooling to room temperature, 250 ml of distilled water and 250 ml of ethyl acetate were added to the reaction mixture. The aqueous phase was decanted and extracted twice with a total of 250 ml of methyl acetate. The combined organic extracts were extracted three times with a total of 750 ml of a 10% aqueous solution of tartaric acid. The combined acid solutions were treated with 5 g of animal charcoal, filtered and rendered alkaline on an ice bath with 96 ml of 10 N aqueous caustic soda. The oil which separated was extracted three times with a total of 1.500 ml of ethyl acetate. The combined organic extracts were washed to neutrality by washing twice with a total of 1 liter of distilled water, dried over anhydrous magnesium sulfate and evaporated under reduced pressure on a water bath at 45°C. 17 g of oil were obtained which was purified by chromatography on an inert alumina column. 13.3 g of crystallized product were obtained. 10-(3-Quinuclidinyl-methyl)-phenothiazine having a MP of 130°C to 131°C was obtained by recrystallization in boiling acetonitrile.
The 3-chloromethyl-quinuclidine hydrochloride used as starting material in this process can be obtained as described by Grob and coll., Helv. Chim. Acta, 37 (1954),1689.
Therapeutic Function
Antihistaminic
Biologische Aktivität
Mequitazine is a potent, nonsedative, long-acting and selective H1 histamine receptor antagonist. Mequitazine exhibits weak anticholinergic activity.

MEQUITAZINE Upstream-Materialien And Downstream Produkte

Mechitazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

29216-28-2, MEQUITAZINE Verwandte Suche:

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