Hydroflumethiazid

Bezeichnung:Hydroflumethiazid

CAS-Nr135-09-1

Englisch Name:HYDROFLUMETHIAZIDE

CBNumberCB5416596

SummenformelC8H8F3N3O4S2

Molgewicht331.29

MOL-Datei135-09-1.mol

Synonyma

Hydroflumethiazid

Hydroflumethiazid physikalisch-chemischer Eigenschaften

Schmelzpunkt	272-273
Siedepunkt	531.6±60.0 °C(Predicted)
Dichte	1.5955 (estimate)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
Löslichkeit	DMSO (Slightly), Methanol (Sparingly)
pka	8.9, 8.2(at 25℃)
Aggregatzustand	Solid
Farbe	White
Wasserlöslichkeit	329.9mg/L(room temperature)
EPA chemische Informationen	2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide (135-09-1)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	42/43
S-Sätze:	36
WGK Germany	2
RTECS-Nr.	DK9625000
Hazard Note	Irritant
HS Code	2935904000
Giftige Stoffe Daten	135-09-1(Hazardous Substances Data)
Toxizität	LD50 in mice (mg/kg): >8000 orally, 750 i.v., 6280 i.p. (Piala)

Gefahreninformationscode (GHS)

HYDROFLUMETHIAZIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Solid
Originator
Saluron,Bristol,US,1959
Verwenden
Labelled Hydroflumethiazide. Antihypertensive; diuretic.
Definition
ChEBI: Hydroflumethiazide is a benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a thiazide.
Manufacturing Process
(a) Preparation of 5-Trifluoromethylaniline-2,4-Disulfonyl Chloride: 113 ml of chlorosulfonic acid was cooled in an ice-bath, and to the acid was added dropwise while stirring 26.6 grams of α,α,α-trifluoro-m-toluidine. 105 grams of sodium chloride was added during 1 to 2 hours, whereafter the temperature of the reaction mixture was raised slowly to 150° to 160°C, which temperature was maintained for 3 hours. After cooling the mixture, ice-cooled water was added, whereby 5-trifluoromethylaniline-2,4-disulfonyl chloride separated out from the mixture.
(b) Preparation of 5-Trifluoromethyl-2,4-Disulfamylaniline: The 5- trifluoromethylaniline-2,4-disulfonyl chloride obtained in step (a) was taken up in ether and the ether solution dried with magnesium sulfate. The ether was removed from the solution by distillation, the residue was cooled to 0°C and 60 ml of ice-cooled, concentrated ammonia water was added while stirring. The solution was then heated for one hour on a steam bath and evaporated in vacuo to crystallization. The crystallized product was 5-trifluoromethyl-2,4- disulfamylaniline, which was filtered off, washed with water and dried in a vacuum exsiccator over phosphorus pentoxide. After recrystallization from a mixture of 30% ethanol and 70% water the compound had a MP of 247° to 248°C.
(e) Preparation of 6-Trifluoromethyl-7-Sulfamyl-3,4-Dihydro-1,2,4- Benzothiadiazine-1,1-Dioxide: 3.2 grams of 5-trifluoromethyl-2,4- disulfamylaniline was added to a solution of 0.33 gram of paraformaldehyde in 25 ml of methyl Cellosolve (2-methoxy ethanol) together with a catalytic amount of p-toluenesulfonic acid, and the mixture was boiled with reflux for 5 hours. The solvent was then distilled off in vacuo, and the residue triturated with 30 ml of ethyl acetate. 6-trifluoromethyl-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide crystallized out. After recrystallization from methanol/water the substance had a MP of 272° to 273°C.
Therapeutic Function
Diuretic, Antihypertensive

HYDROFLUMETHIAZIDE Upstream-Materialien And Downstream Produkte

Hydroflumethiazid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

135-09-1, HYDROFLUMETHIAZIDE Verwandte Suche:

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