PHENYRAMIDOL Struktur

Fenyramidol

Bezeichnung:Fenyramidol

CAS-Nr553-69-5

Englisch Name:PHENYRAMIDOL

CBNumberCB5408779

SummenformelC13H14N2O

Molgewicht214.26

MOL-Datei553-69-5.mol

Synonyma

Fenyramidol

Fenyramidol physikalisch-chemischer Eigenschaften

Schmelzpunkt	82-85°
Siedepunkt	354.4°C (rough estimate)
Dichte	1.0850 (rough estimate)
Brechungsindex	1.6450 (estimate)
pka	5.85(at 25℃)
EPA chemische Informationen	Fenyramidol (553-69-5)

Sicherheit

Toxizität

LD50 oral in rat: 756mg/kg

PHENYRAMIDOL Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Analexin, Mallinckrodt Inc., US ,1960
Verwenden
Analgesic; relaxant (skeletal muscle).
Verwenden
(±)-Phenyramidol can be used in biological study of preparation of nitric oxide releasing prodrugs useful in the treatment of diseases. It is also a muscle relaxant drug.
Definition
ChEBI: Fenyramidol is an aminopyridine.
Manufacturing Process
A mixture containing 188 g (0.20 mol) of 2-arninopyridine, 0.55 g of lithium amide and 75 cc of anhydrous toluene was refluxed for 1.5 hours. Styrene oxide (12.0 g = 0.10 mol) was then added to the reaction mixture with stirring over a period of ten minutes. The reaction mixture was stirred and refluxed for an additional 3.5 hours. A crystalline precipitate was formed during the reaction which was removed by filtration, MP 170°C to 171°C. 1.5 g. The filtrate was concentrated to dryness and a dark residue remained which was crystallized from anhydrous ether; yield 6.0 g. Upon recrystallization of the crude solid from 30 cc of isopropyl alcohol, 2.0 g of a light yellow solid was isolated; MP 170° to 171°C.
Therapeutic Function
Analgesic, Muscle relaxant
Synthesis Reference(s)
Journal of the American Chemical Society, 81, p. 4351, 1959 DOI: 10.1021/ja01525a062
Allgemeine Beschreibung
Crystals (from dilute methanol).
Reaktivität anzeigen
PHENYRAMIDOL is an amine and an alcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Brandgefahr
Flash point data for PHENYRAMIDOL are not available. PHENYRAMIDOL is probably combustible.

PHENYRAMIDOL Upstream-Materialien And Downstream Produkte

Fenyramidol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

553-69-5, PHENYRAMIDOL Verwandte Suche:

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