Gimeracil

Bezeichnung:Gimeracil

Englisch Name:Gimeracil

CBNumberCB5362004

SummenformelC5H4ClNO2

Molgewicht145.54

Gimeracil physikalisch-chemischer Eigenschaften

Schmelzpunkt	274 °C
Siedepunkt	255.1±40.0 °C(Predicted)
Dichte	1.56±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Soluble in DMSO (up to 5 mg/ml).
Aggregatzustand	solid
pka	4.50±1.00(Predicted)
Farbe	White
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey	ZPLQIPFOCGIIHV-UHFFFAOYSA-N
CAS Datenbank	103766-25-2(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
HS Code	29337900

Gefahreninformationscode (GHS)

Beschreibung
Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2? Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3
Chemische Eigenschaften
Off-White Solid
Verwenden
Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.
Verwenden
Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD)
Verwenden
Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).
Definition
ChEBI: Gimeracil is an organic molecular entity.
Einzelnachweise
1) Diasio (1999)?Clinical implications of dihydropyrimidine dehydrogenase inhibition; Oncology(Williston Park),?13?17 2) Kobayakawa and Kojima (2011),?Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies; Onco. Targets Ther.,?4?193 3) Sakata?et al.?(2011),?Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination; Cancer Sci.,?102?1712