Prednicarbat

Bezeichnung:Prednicarbat

Englisch Name:Prednicarbate

CBNumberCB5342987

SummenformelC27H36O8

Molgewicht488.57

Synonyma

Prednicarbat

Prednicarbat physikalisch-chemischer Eigenschaften

Schmelzpunkt	110-112°; mp 183°
alpha	D20 +63° (c = 0.1 in ethanol)
Siedepunkt	640.7±55.0 °C(Predicted)
Dichte	1.25±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
Löslichkeit	Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent), sparingly soluble in propylene glycol. It shows polymorphism (5.9).
pka	14.05±0.70(Predicted)
Farbe	White to Off-White

Sicherheit

HS Code

2937290000

Gefahreninformationscode (GHS)

Beschreibung
Prednicarbate is a potent topical antiinflammatory agent with minimal systemic effects. It is useful in the treatment of cutaneous inflammatory disorders such as eczema and psoriasis.
Beschreibung
Prednicarbate is a synthetic corticosteroid and a derivative of prednisolone . It has anti-inflammatory activity comparable to that of desoximetasone in various murine models when administered topically but lacks activity when administered subcutaneously. Topical administration of prednicarbate (2 drops of a 0.1% solution per day) induces wound healing in hairless mice. Formulations containing prednicarbate have been used to treat chronic hand eczema.
Chemische Eigenschaften
White or almost white, crystalline powder.
Originator
Hoechst AG (W. Germany)
Verwenden
Topical anti-inflammatory agent. Glucocorticoid.
Prednicarbate (Dermatop E) is a synthetic nonfluorinated topical corticosteroid.
Definition
ChEBI: Prednicarbate is a corticosteroid hormone.
Indications
Prednicarbate (Dermatop E) is a synthetic nonfluorinated topical corticosteroid.
Trademarks
Dermatop (Sanofi Aventis).
Allgemeine Beschreibung
Prednicarbate, 17-[(ethoxycarbonyl)oxy]-11β-hydroxy-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione, is a prednisolone derivative with a C21 propionateester and a C17 ethyl carbonate group. It is availablefor use only in a 0.1% topical cream. Prednicarbate is amedium-potency GC.