Apafant Struktur

Apafant

Bezeichnung:Apafant

CAS-Nr105219-56-5

Englisch Name:Apafant

CBNumberCB5252385

SummenformelC22H22ClN5O2S

Molgewicht455.96

MOL-Datei105219-56-5.mol

Apafant physikalisch-chemischer Eigenschaften

Schmelzpunkt	186-188°C
Siedepunkt	720.2±70.0 °C(Predicted)
Dichte	1.48
storage temp.	2-8°C
Löslichkeit	DMSO: soluble10mg/mL (clear solution)
pka	2.36±0.40(Predicted)
Aggregatzustand	powder
Farbe	white to beige
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Sicherheit

WGK Germany	3
Toxizität	LD50 in mice (mg/kg): 540 i.v.; 4600 orally (Casals-Stenzel)

Gefahreninformationscode (GHS)

Apafant Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
WEB-2086 (105219-56-5) is a potent and selective antagonist of the platelet activating factor (PAF) receptor (Ki = 16.3 nM).1?Displays an activity profile which includes antiinflammatory, antiangiogenesis and anticancer activity.2?Along with leukotriene antagonists, WEB-2086 cooperatively provides a robust antiinflammatory effect regulating PMNL migration and edema formation.3?Displays analgesic effects in animal models of neuropathic pain.4?Active in vivo.
Chemische Eigenschaften
White Solid
Verwenden
Platelet activating factor (PAF) antagonist.
Verwenden
Tool to evaluate the role of PAF in experimental models of human disease.
Definition
ChEBI: LSM-2613 is an organonitrogen heterocyclic compound and an organosulfur heterocyclic compound.
Biologische Aktivität
Potent, selective platelet-activating factor (PAF) receptor antagonist (K i = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.
Biochem/physiol Actions
WEB2086 is a very potent, selective platelet-activating factor (PAF) antagonist (IC50 = 16 nM). WEB2086 inhibits the proliferation of tumor cells and slows tumor growth in xenograft tumor models, and has been shown to inhibit angiogenesis.
Lager
Desiccate at +4°C
Einzelnachweise
1) Dent et al. (1989), Characterization of PAF receptors on human neutrophils using the specific antagonist WEB 2086. Correlation between receptor binding and function; FEBS Lett., 244 365 2) Cellai et al. (2006), Growth inhibition and differentiation of human breast cancer cells by PAFR antagonist WEB-2086; Br. J. Cancer, 94 1637 3) Bitencourt et al. (2013), Cooperative role of endogenous leucotrienes and platelet-activating factor in ischaemia-reperfusion-mediated tissue injury; J. Cell. Mol. Med., 17 1554 4) Motoyama et al. (2013), Pain-releasing action of platelet-activating factor (PAF) antagonists in neuropathic pain animal models and the mechanisms of action; Eur. J. Pain, 17 1156

Apafant Upstream-Materialien And Downstream Produkte

Apafant Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

105219-56-5, Apafant Verwandte Suche:

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