2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

Bezeichnung:2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

CAS-Nr56741-95-8

Englisch Name:2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

CBNumberCB5225165

SummenformelC10H8BrN3O

Molgewicht266.09

MOL-Datei56741-95-8.mol

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	285-287° (Stevens); mp 246-248° (Brown, Stevens)
Siedepunkt	389.7±52.0 °C(Predicted)
Dichte	1.6292 (rough estimate)
Brechungsindex	1.6520 (estimate)
storage temp.	room temp
Löslichkeit	DMSO: ≥5mg/mL (warm DMSO)
Aggregatzustand	powder
pka	3.18; 8.53(at 25℃)
Farbe	white to beige
Wasserlöslichkeit	7.8mg/L(37 ºC)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	63-62
WGK Germany	3
RTECS-Nr.	UW7351300

Gefahreninformationscode (GHS)

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).
Verwenden
Bropirimine, an immunostimulating agent and toll like receptor (TLR7) agonist, is used in comparison with other TLR7 agonists such as imiquimod, R-848, loxoribine in interferon cell signaling research. Bropirimine may be used in experimental autoimmune encephalomyelitis (EAE) and bladder cancer research.
Verwenden
Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect.
Definition
ChEBI: Bropirimine is a member of pyrimidines.
Biochem/physiol Actions
Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.
Lager
Desiccate at RT

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

56741-95-8, 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Verwandte Suche:

Send Inquriy