N-(Aminocarbonyl)-2-brom-3-methyl-butansäureamid

Bezeichnung:N-(Aminocarbonyl)-2-brom-3-methyl-butansäureamid

Englisch Name:Bromisoval

CBNumberCB3138005

SummenformelC6H11BrN2O2

Molgewicht223.07

Synonyma

Bromisoval

N-(Aminocarbonyl)-2-brom-3-methyl-butansäureamid

N-(Aminocarbonyl)-2-brom-3-methyl-butansäureamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	152 °C
Dichte	1.6005 (rough estimate)
Brechungsindex	1.5410 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	10.54±0.70(Predicted)
Farbe	White to Off-White
Wasserlöslichkeit	19.03g/L(temperature not stated)
Merck	14,1397
InChIKey	CMCCHHWTTBEZNM-UHFFFAOYSA-N
CAS Datenbank	496-67-3(CAS DataBase Reference)
NIST chemische Informationen	Bromisovalum(496-67-3)
EPA chemische Informationen	Butanamide, N-(aminocarbonyl)-2-bromo-3-methyl- (496-67-3)

Sicherheit

RTECS-Nr.	YS3150000
HS Code	2924.19.8000
Toxizität	LD50 in male mice (mmoles/kg): 3.25 i.p. (Mrongovius)

Gefahreninformationscode (GHS)

Chemische Eigenschaften
White Solid
Originator
Bromisovalum,Linhai Duqiao Fine Chemical Factory
Verwenden
2-Bromo-3-methylbutyrylurea is a hypnotic and sedative drug marketed over the counter in Asian under various brand names.
Definition
ChEBI: An N-acylurea that is urea in which one of the hydrogens is replaced by a 2-bromo-3-methybutanoyl group.
Manufacturing Process
A mixture of 2 kg 2-bromoisovalerylbromide and 1 kg dry urea is heated at 70°C. Then to the reaction mixture is added sodium hydrogen carbonate. 2- Bromo-3-methylbutyrylurea is recrystallized from toluene or water, melting point 149°C.
Trademarks
Bromural (Knoll).
Therapeutic Function
Sedative, Hypnotic
Weltgesundheitsorganisation (WHO)
Bromisoval is a monureide sedative of long standing. It remains available in several countries. However, it releases the bromide ion and prolonged usage can result in chronic bromide accumulation and intoxication.
Sicherheitsprofil
Moderately toxic by ingestion. Human systemic effects by ingestion: nausea or vomiting, and coma. A sedative and hypnotic agent. When heated to decomposition it emits very toxic fumes of Brand NOx
läuterung methode
Crystallise it from aqueous EtOH or toluene, and dry it in air. [Beilstein 3 H 63, 3 I 29, 3 II 51, 3 III 123, 3 IV 117.]