2-BROMO-ISONICOTINIC ACID METHYL ESTER

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-BROMO-ISONICOTINIC ACID METHYL ESTER Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  Colorless liquid or solid

• Verwenden

  2-Bromopyridine-4-carboxylic acid methyl ester is a kind of important medicine intermediate,  used as initiator during the synthesis of polymer brushes with single-walled carbon nanotubes as backbones.

• Synthese

  

  67-56-1

  

  66572-56-3

  

  26156-48-9

  To a 250 mL round bottom flask was added a methanol (100 mL) solution of 2-bromo-4-pyridinecarboxylic acid (10 g, 49.50 mmol, 1.00 equiv) and concentrated sulfuric acid (98%, 5 mL). The reaction mixture was stirred at 70 °C overnight. Upon completion of the reaction, the solution was concentrated under reduced pressure to remove the solvent. The residue was dissolved in 200 mL of ethyl acetate (EtOAc) and washed with saturated sodium bicarbonate solution (3 x 150 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure to give 10 g (94% yield) of methyl 2-bromopyridine-4-carboxylate as a colorless oil.

• Einzelnachweise

  [1] Patent: WO2016/138335, 2016, A1. Location in patent: Paragraph 00319
  [2] Patent: WO2016/34675, 2016, A1. Location in patent: Page/Page column 69
  [3] Patent: US2011/111046, 2011, A1. Location in patent: Page/Page column 18
  [4] Patent: WO2011/58473, 2011, A1. Location in patent: Page/Page column 37
  [5] Journal of Organic Chemistry, 2009, vol. 74, # 19, p. 7441 - 7448

2-BROMO-ISONICOTINIC ACID METHYL ESTER Upstream-Materialien And Downstream Produkte

2-BROMO-ISONICOTINIC ACID METHYL ESTER Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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