pipradrol hydrochloride Struktur

alpha, alpha-Diphenyl-2-piperidin-methanol-hydrochlorid

Bezeichnung:alpha, alpha-Diphenyl-2-piperidin-methanol-hydrochlorid

CAS-Nr71-78-3

Englisch Name:pipradrol hydrochloride

CBNumberCB4875642

SummenformelC18H21NO.ClH

Molgewicht303.831

MOL-Datei71-78-3.mol

Synonyma

Pipradrolhydrochlorid

alpha, alpha-Diphenyl-2-piperidin-methanol-hydrochlorid

alpha, alpha-Diphenyl-2-piperidin-methanol-hydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	298-300?C
storage temp.	Controlled Substance, -20°C Freezer
Löslichkeit	DMSO: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 0.5 mg/ml
Aggregatzustand	A crystalline solid

pipradrol hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Pipradrol is a mild stimulant containing a piperidine ring. Once used as a treatment for obesity and dementia, pipradrol is now regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
Chemische Eigenschaften
White Solid
Originator
Alertonic ,Adcock Ingram Ltd.
Verwenden
Controlled substance (stimulant). CNS stimulant
Definition
ChEBI: Pipradrol hydrochloride is a diarylmethane.
Manufacturing Process
A mixture of 48 g (0.167 mole) of α,α-diphenyl-2-pyridinemethanol hydrochloride (Emraert et al., Ber. 72B, 1188 (1939); 74B, 714 (1940), 160 ml of ethanol, and 3 0.5 g of Adams' platinum catalyst was shaken under an initial hydrogen pressure of 60 pounds. The theoretical amount of hydrogen was absorbed in 5 hours. The reaction mixture was refluxed, diluted with enough water to dissolve all the white solid, and filtered hot from the catalyst. The filtrate was cooled and filtered; yield of 38 g of α,α-diphenyl-alpha-(2piperidyl)methanol white product melting at 308-309°C with decomposition.
A mixture of 3.5 grams (0.013 mole) of the above α,α-diphenyl-alpha-(2piperidyl)methanol, 4 g (0.05 mole) of formaldehyde (37%), and 6 grams (0.1 mole) of formic acid was refluxed for 2 days. The reaction mixture was treated with 1.3 g (0.013 mole) of conc. hydrochloric acid and vacuum distilled on the steam bath. The residue was recrystallized from butanone to give the α,αdiphenyl-alpha-(2-piperidyl)methanol hydrochloride which melted at 228229°C (dec.).
Trademarks
Meratran (Marion Merrell Dow).
Therapeutic Function
Central stimulant
Sicherheitsprofil
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of HCl and NOx.

pipradrol hydrochloride Upstream-Materialien And Downstream Produkte

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