Diloxanide furoate Struktur

4-[(Dichloracetyl)methylamino]phenyl-2-furoat

Bezeichnung:4-[(Dichloracetyl)methylamino]phenyl-2-furoat

CAS-Nr3736-81-0

Englisch Name:Diloxanide furoate

CBNumberCB4723149

SummenformelC14H11Cl2NO4

Molgewicht328.15

MOL-Datei3736-81-0.mol

Synonyma

4-[(Dichloracetyl)methylamino]phenyl-2-furoat

4-[(Dichloracetyl)methylamino]phenyl-2-furoat physikalisch-chemischer Eigenschaften

Schmelzpunkt	111-114 °C
Siedepunkt	438.4±45.0 °C(Predicted)
Dichte	1.424±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	-0?+-.0.50(Predicted)
Farbe	Off-White to Light Beige
BCS Class	4
CAS Datenbank	3736-81-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
WGK Germany	3
RTECS-Nr.	LV1821800
HS Code	2924296000
Toxizität	mouse,LDLo,oral,710mg/kg (710mg/kg),Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985.

Gefahreninformationscode (GHS)

Diloxanide furoate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Furamide is an ambecide, an anti-protozoal drug used in the treatment of amoebozoa infections.
Verwenden
Antidiarrhoeals / Antiprotozoles
Verwenden
selective agonist for delta-opioid receptor
Definition
ChEBI: Diloxanide furoate is a carboxylic ester resulting from the formal condensation of the carboxy group of furan-2-carboxylic acid with the hydroxy group of 2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide. It is a drug used for the treatment of asymptomatic amebiasis. It has a role as an antiamoebic agent and a prodrug. It is a member of furans, a carboxylic ester, a tertiary carboxamide and an organochlorine compound.
Indications
Diloxanide furoate (Furamide) is an amebicide that is effective against trophozoites in the intestinal tract. In mild or asymptomatic infections, cures of 83 to 95% have been achieved; in patients with dysentery, cure rates may be less impressive. The drug is administered only orally and is rapidly absorbed from the gastrointestinal tract following hydrolysis of the ester group. It is remarkably free of side effects, but occasionally flatulence, abdominal distention, anorexia, nausea, vomiting, diarrhea, pruritus, and urticaria occur. Diloxanide is excreted in the urine, largely as the glucuronide. It is not available in the United States.
Clinical Use
Diloxanide furoate (available from the Centers for Disease Control and Prevention [CDC]) is prescribed for the treatment of asymptomatic amebiasis but is ineffective as a single agent for the extraintestinal form of the disease. The drug is administered orally and is hydrolyzed in the gut to give diloxanide, which is considered to be the active drug. Diloxanide is the only form identified in the bloodstream. The drug is found in the urine as the glucuronide.

4-[(Dichloracetyl)methylamino]phenyl-2-furoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3736-81-0, Diloxanide furoate Verwandte Suche:

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