5-Methoxy-2-phenyl-4-benzopyron

Bezeichnung:5-Methoxy-2-phenyl-4-benzopyron

CAS-Nr42079-78-7

Englisch Name:5-METHOXYFLAVONE

CBNumberCB4688875

SummenformelC16H12O3

Molgewicht252.26

MOL-Datei42079-78-7.mol

Synonyma

5-Methoxy-2-phenyl-4-benzopyron

5-Methoxy-2-phenyl-4-benzopyron physikalisch-chemischer Eigenschaften

Schmelzpunkt	131-133°C
Siedepunkt	422.5±45.0 °C(Predicted)
Dichte	1,155g/cm
Brechungsindex	1,548
storage temp.	Store at -20°C
Löslichkeit	soluble in Methanol
Aggregatzustand	powder to crystal
Farbe	White to Almost white
LogP	3.470 (est)
CAS Datenbank	42079-78-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36/37/39-36
WGK Germany	3
HS Code	2932.99.7000

Gefahreninformationscode (GHS)

5-METHOXYFLAVONE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
5-Methoxyflavone is a flavenoid and dietary derived inhibitor of cell proliferation.
Definition
ChEBI: 5-Methoxyflavone is an ether and a member of flavonoids.
Biologische Aktivität
5-Methoxyflavone, a flavonoid, is an inhibitor of DNA polymerase-beta and a neuroprotectant against beta-amyloid toxicity. Possesses central nervous system sedative effect by regulating ionophilic GABAA receptors.
in vitro

5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. It (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF , 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 ( DR5) in a time-dependent manner.
in vivo

5-Methoxyflavone (100, 150 mg/kg, ip) significantly decreases the latency time to loss of righting reflex. It (50, 100 and 150 mg/kg, ip) exhibits a significant and dose decreases -dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, ip) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, ip) completely abolishesed the grooming response similar to diazepam treated animals.
target

Target Value
DNA polymerase β
()

5-METHOXYFLAVONE Upstream-Materialien And Downstream Produkte

5-Methoxy-2-phenyl-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

42079-78-7, 5-METHOXYFLAVONE Verwandte Suche:

Send Inquriy

Target	Value
DNA polymerase β ()