5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4-benzopyron

Bezeichnung:5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4-benzopyron

CAS-Nr481-53-8

Englisch Name:Tangeretin

CBNumberCB3409585

SummenformelC20H20O7

Molgewicht372.37

MOL-Datei481-53-8.mol

Synonyma

5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4-benzopyron

5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4-benzopyron physikalisch-chemischer Eigenschaften

Schmelzpunkt	153.0 to 157.0 °C
Siedepunkt	565.3±50.0 °C(Predicted)
Dichte	1.244±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO : 25 mg/mL (67.14 mM; Need ultrasonic)
Aggregatzustand	Solid
Farbe	White to Almost white
BRN	351695
Major Application	food and beverages
Kosmetik-Inhaltsstoffe Funktionen	SKIN CONDITIONING ANTIOXIDANT
InChI	InChI=1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3
InChIKey	ULSUXBXHSYSGDT-UHFFFAOYSA-N
SMILES	C1(C2=CC=C(OC)C=C2)OC2=C(OC)C(OC)=C(OC)C(OC)=C2C(=O)C=1
LogP	1.788 (est)
CAS Datenbank	481-53-8(CAS DataBase Reference)
NIST chemische Informationen	Tangeretin(481-53-8)

Sicherheit

Kennzeichnung gefährlicher	T,Xi
R-Sätze:	25-36/37/38
S-Sätze:	45-36-26
RIDADR	UN 2811
WGK Germany	3
RTECS-Nr.	DJ3102725
HS Code	29329990
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral
Toxizität	rat,LD50,intraperitoneal,> 1gm/kg (1000mg/kg),Advances in Teratology. Vol. 3, Pg. 181, 1968.

Gefahreninformationscode (GHS)

Tangeretin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Tangeretin is a yellow crystal that is volatile, difficult to dissolve in water, and easily soluble in organic solvents such as ethanol and ether. It is the active ingredient in tangerine peel. It has a good effect in treating animal mites.
Verwenden
Tangeretin has been used as an antioxidant and antifungal agent to test its effects on ferroptosis inhibition, conidial development, and appressorium formation against Magnaporthe oryzae. It has also been used as a co-chemotherapeutics agent to study its cytotoxic effects in combination with 5-Fluorouracil (5-Fu) on WiDr colon cancer cells.
Definition
ChEBI: Tangeretin is a pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8. It has a role as an antineoplastic agent and a plant metabolite.
Allgemeine Beschreibung
Tangeretin is a polymethoxyflavone extracted primarily from the peels of citrus fruits like Citrus sinensis and Citrus reticulata.
Biologische Aktivität
Tangeretin is a flavonoid found in the peel of citrus fruits where it most likely provides natural resistance to fungi. Tangeretin has been shown to counteract tumor promoter-induced inhibition of intercellular communication and to inhibit cell proliferation in several cancer lines.
in vivo

In this study, we investigated the in vivo anti-RSV activity of tangeretin in 3-week-old male BALB/c mice. A plaque reduction assay and fluorescence quantitative polymerase chain reaction (FQ-PCR) showed that tangeretin inhibited RSV replication in the lung of mice^[2].

Tangeretin Upstream-Materialien And Downstream Produkte

5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

481-53-8, Tangeretin Verwandte Suche:

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