Carnosic acid

Bezeichnung:Carnosic acid

CAS-Nr3650-09-7

Englisch Name:Carnosic acid

CBNumberCB4367749

SummenformelC20H28O4

Molgewicht332.43

MOL-Datei3650-09-7.mol

Carnosic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	190°C(lit.)
Siedepunkt	506.4±50.0 °C(Predicted)
Dichte	1.184±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	powder
pka	4.14±0.40(Predicted)
Farbe	yellow
BRN	2707918
InChIKey	QRYRORQUOLYVBU-VBKZILBWSA-N
LogP	5.405 (est)
CAS Datenbank	3650-09-7(CAS DataBase Reference)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
HS Code	29182900

Gefahreninformationscode (GHS)

Carnosic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Yellow powder
Verwenden
Carnosic Acid is a phenolic component of rosemary. It acts as a potent antioxdant and also has UV protective activity. Specifically protection for UV-A radiation and damage. Carnosic Acid also inhibits the free-radical chain reaction that leads to the oxidation of fats and oils, thereby stabilizing and increasing the shelf life of meats.
Definition
ChEBI: An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from Rosmarinus officinalis and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.
Anticancer Research
Carnosic acid is a diterpene found in rosemary (Rosmarinus officinalis), exhibitinganti-proliferative effects when observed in vitro in human renal carcinoma cells andcervical carcinoma cells (Su et al. 2016) including inhibition of cell proliferation,angiogenesis and cell migration. ER stress is induced by the carnosic acid present inthe extract from rosemary, inducing cancer cell apoptosis (Cao and Kaufman 2014;Petiwala et al. 2014). Carnosic acid induced dose-dependent expression of ATF4and CHOP and knockdown of CHOP and ATF4 by siRNA-suppressed apoptosis.
The role of ROS was investigated in the induction of ER stress by carnosic acid.ATF4 and CHOP expression induced by carnosic acid was markedly inhibited byROS scavengers. Hence, this information implies that ATF4 and CHOP expressionmediated by ER stress plays a significant part in apoptosis of human kidney Cakicells induced by carnosic acid (Min et al. 2014). Treatment of 22Rv1 and LNCaP,human prostate cancer cell lines, by carnosic acid degraded the androgen receptor(AR), and antigen specific to the prostate also showed reduced expression.Proteasomal degradation pathway dependent on ER stress mediates AR degradation.Induction of CHOP protein, degradation of AR and reduction in the growth ofxenograft prostate cancer tumours by 53% were also detected in vivo. Additionally,carnosic acid induces ER stress only in prostate cancer cells and not in normal cells(Petiwala et al. 2016).

Carnosic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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