Oligomycin A

Bezeichnung:Oligomycin A

CAS-Nr579-13-5

Englisch Name:OLIGOMYCIN A

CBNumberCB4274065

SummenformelC45H74O11

Molgewicht791.06

MOL-Datei579-13-5.mol

Synonyma

Oligomycin A

Oligomycin A physikalisch-chemischer Eigenschaften

Schmelzpunkt	150-151℃
Siedepunkt	886.3±65.0 °C(Predicted)
Dichte	1.14
storage temp.	Sealed in dry,Store in freezer, under -20°C
Löslichkeit	Soluble in DMSO, ethanol or acetone
pka	12.52±0.70(Predicted)
Aggregatzustand	powder
Farbe	white to off-white
Merck	13,6902
BRN	5702132
InChIKey	MNULEGDCPYONBU-WMBHJXFZSA-N

Sicherheit

Kennzeichnung gefährlicher	Xn,T
R-Sätze:	22-68/20/21/22-20/21/22
S-Sätze:	36/37-24/25
RIDADR	2811
WGK Germany	3
RTECS-Nr.	RK3325000
F	3-10
HazardClass	6.1(b)
PackingGroup	III
HS Code	29419090

Gefahreninformationscode (GHS)

OLIGOMYCIN A Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R68/20/21/22:Gesundheitsschädlich: Möglichkeit irreversiblen Schadens durch Einatmen,Berührung mit der Haut und durch Verschlucken.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin A, a dominant analog of the isomers, is an inhibitor of mitochondrial F₁F_O ATP synthase that induces apoptosis in a variety of cell types (average GI₅₀ = 270 nM). Oligomycin A exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents, which limits its clinical application.
Chemische Eigenschaften
White powder
Verwenden
Oligomycin A is the dominant analogue of a class of macrocyclic lactones isolated from selected strains of Streptomyces sp.. Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin A exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.
Verwenden
Oligomycin A is the dominant analogue of a class macrocyclic lactones isolated from selected strains of Streptomyces sp.. Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin A exhibits a broad biological profile including antifungal, antitumour and nematocidal activities.
Verwenden
Oligomycin A is a macrolide with fungicidal activity isolated from Streptomyces species.
Lager
-20°C
Einzelnachweise
[1]. jastroch m, divakaruni as, mookerjee s, et al. mitochondrial proton and electron leaks. essays biochemistry, 2010, 47:53-67.
[2]. shchepina la, pletjushkina oy, avetisyan av, et al. oligomycin, inhibitor of the f-0 part of h+-atp-synthase, suppresses the tnf-induced apoptosis. oncogene, 2002, 53: 8149-8157.
[3]. salomon ar, voehringer dw, herzenberg la, et al. understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of f0f1-atpase. proceedings of the national academy of sciences of the united states of america, 2000, 97(26): 14766-14771.
[4]. alexander r, adina v, ivan b,　et al. overcoming intrinsic multi-drug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling jarid1bhigh cells. cancer cell, 2013, 23(6): 811-825.

Oligomycin A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

579-13-5, OLIGOMYCIN A Verwandte Suche:

Send Inquriy