11-Aminoundecansure

Bezeichnung:11-Aminoundecansure

CAS-Nr2432-99-7

Englisch Name:11-Aminoundecanoic acid

CBNumberCB4187611

SummenformelC11H23NO2

Molgewicht201.31

MOL-Datei2432-99-7.mol

Synonyma

11-Aminoundecansure

11-Aminoundecansure physikalisch-chemischer Eigenschaften

Schmelzpunkt	188-191 °C (lit.)
Siedepunkt	339.24°C (rough estimate)
Dichte	0.9896 (rough estimate)
Brechungsindex	1.4420 (estimate)
storage temp.	Store below +30°C.
Löslichkeit	2g/l
pka	4.78±0.10(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	White
Wasserlöslichkeit	2 g/L (20 ºC)
BRN	1767291
InChIKey	GUOSQNAUYHMCRU-UHFFFAOYSA-N
LogP	-0.16 at 20℃
CAS Datenbank	2432-99-7(CAS DataBase Reference)
IARC	3 (Vol. 39, Sup 7) 1987
EPA chemische Informationen	11-Aminoundecanoic acid (2432-99-7)

Sicherheit

R-Sätze:	52
S-Sätze:	24/25
WGK Germany	1
RTECS-Nr.	YQ2293000
HS Code	29224995
Giftige Stoffe Daten	2432-99-7(Hazardous Substances Data)
Toxizität	LDLo orl-rat: 14,700 mg/kg NTPTR* NTP-TR-216,82

Gefahreninformationscode (GHS)

11-Aminoundecanoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Aminoundecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. Aminoundecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
Chemische Eigenschaften
White crystalline powder
Chemische Eigenschaften
11-Aminoundecanoic acid is a solid.
Verwenden
11-Aminoundecanoic Acid is used to prepare thapsigargin analogues targeting apoptosis to prostatic cancer cells. It is also used to synthesize N-carboxyalkylpeptides containing extended alkyl residues at P1''as matrix metalloproteinase inhibitors.
Definition
ChEBI: 11-Aminoundecanoic acid is a medium-chain fatty acid.
synthetische
|?-Aminoundecanoic acid is normally prepared from castor oil (glycerol triricinoleate). Firstly the castor oil is subjected to methanolysis to yield the methyl ester of ricinoleic acid and then the following route is used:

In the first step, the pyrolysis of methyl ricinoleate is carried out at about 500??C; the principal products are n-heptaldehyde and methyl undecylenate. The latter is hydrolysed to give undecylenic acid which is treated with hydrogen bromide in a non-polar solvent in the presence of a peroxide. Under these conditions, reverse Markownikoff addition occurs and the main product is |?-bromoundecanoic acid. This product is then treated with ammonia to give |?-aminoundecanoic acid, which is a crystalline solid, m.p. 189??C.
Allgemeine Beschreibung
White crystalline solid or powder.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
11-Aminoundecanoic acid is incompatible with strong oxidizing agents, strong acids and strong bases.
Brandgefahr
Flash point data for 11-Aminoundecanoic acid are not available; however, 11-Aminoundecanoic acid is probably combustible.
Flammability and Explosibility
Non flammable
Sicherheitsprofil
Poison by ingestion. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.

11-Aminoundecanoic acid Upstream-Materialien And Downstream Produkte

11-Aminoundecansure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2432-99-7, 11-Aminoundecanoic acid Verwandte Suche:

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